Human Gene KRTAP22-1 (uc011add.2)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: KR221_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 22-1;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. SUBUNIT: Interacts with hair keratins (By similarity).
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR021743 - KRTAP
Pfam Domains: PF11759 - Keratin-associated matrix
ModBase Predicted Comparative 3D Structure on Q3MIV0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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KJ904184 - Synthetic construct Homo sapiens clone ccsbBroadEn_13578 KRTAP22-1 gene, encodes complete protein. AB096953 - Homo sapiens KRTAP22-1 mRNA for keratin associated protein, complete cds. BC101686 - Homo sapiens keratin associated protein 22-1, mRNA (cDNA clone MGC:126735 IMAGE:8069192), complete cds. BC101682 - Homo sapiens keratin associated protein 22-1, mRNA (cDNA clone MGC:126731 IMAGE:8069188), complete cds.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: KAP22.1, KR221_HUMAN, NM_181620, NP_853651, Q3MIV0 UCSC ID: uc011add.2 RefSeq Accession: NM_181620
Protein: Q3MIV0
(aka KR221_HUMAN)
CCDS: CCDS13601.1
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Gene Model Information
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category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_181620.1
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exon count:
| 1 | CDS single in 3' UTR:
| no
| RNA size:
| 147 |
ORF size:
| 147 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 394.00 | frame shift in genome:
| no
| % Coverage:
| 100.00 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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