Human Gene KRTAP19-3 (uc002yog.1)
  Description: Homo sapiens keratin associated protein 19-3 (KRTAP19-3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr21:31,863,782-31,864,275 Size: 494 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr21:31,864,030-31,864,275 Size: 246 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:31,863,782-31,864,275)mRNA (may differ from genome)Protein (81 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
ReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KR193_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 19-3; AltName: Full=GTHRP; AltName: Full=Glycine/tyrosine-rich protein;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
SUBUNIT: Interacts with hair keratins (By similarity).
SIMILARITY: Belongs to the KRTAP type 19 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.50 RPKM in Muscle - Skeletal
Total median expression: 0.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -31.90248-0.129 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021743 - KRTAP

Pfam Domains:
PF11759 - Keratin-associated matrix

ModBase Predicted Comparative 3D Structure on Q7Z4W3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0031424 keratinization

Cellular Component:
GO:0005829 cytosol
GO:0005882 intermediate filament


-  Descriptions from all associated GenBank mRNAs
  AF139541 - Homo sapiens glycine/tyrosine-rich protein mRNA, complete cds.
AB096944 - Homo sapiens KRTAP19-3 mRNA for keratin associated protein, complete cds.
BC126280 - Homo sapiens cDNA clone IMAGE:8991996.
BC126282 - Homo sapiens cDNA clone IMAGE:8991998.
BC148791 - Synthetic construct Homo sapiens clone IMAGE:100015839, MGC:183191 keratin associated protein 19-3 (KRTAP19-3) mRNA, encodes complete protein.
BC148585 - Synthetic construct Homo sapiens clone IMAGE:100015539, MGC:183086 keratin associated protein 19-3 (KRTAP19-3) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z4W3 (Reactome details) participates in the following event(s):

R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: KAP19.3, KR193_HUMAN, NM_181609, NP_853640, Q7Z4W3
UCSC ID: uc002yog.1
RefSeq Accession: NM_181609
Protein: Q7Z4W3 (aka KR193_HUMAN)
CCDS: CCDS13596.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_181609.3
exon count: 1CDS single in 3' UTR: no RNA size: 494
ORF size: 246CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 693.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.