Human Gene KRTAP19-2 (uc011acy.2)
  Description: Homo sapiens keratin associated protein 19-2 (KRTAP19-2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr21:31,859,509-31,859,667 Size: 159 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr21:31,859,509-31,859,667 Size: 159 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:31,859,509-31,859,667)mRNA (may differ from genome)Protein (52 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
ReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KR192_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 19-2;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
SUBUNIT: Interacts with hair keratins (By similarity).
SIMILARITY: Belongs to the KRTAP type 19 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021743 - KRTAP

Pfam Domains:
PF11759 - Keratin-associated matrix

ModBase Predicted Comparative 3D Structure on Q3LHN2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0031424 keratinization

Cellular Component:
GO:0005829 cytosol
GO:0005882 intermediate filament


-  Descriptions from all associated GenBank mRNAs
  AB180041 - Homo sapiens KRTAP19-2 mRNA for keratin associated protein, complete cds.
BC148695 - Synthetic construct Homo sapiens clone IMAGE:100015652, MGC:183144 keratin associated protein 19-2 (KRTAP19-2) mRNA, encodes complete protein.
BC140341 - Synthetic construct Homo sapiens clone IMAGE:100014381, MGC:173234 keratin associated protein 19-2 (KRTAP19-2) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q3LHN2 (Reactome details) participates in the following event(s):

R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: KAP19.2, KR192_HUMAN, NM_181608, NP_853639, Q3LHN2
UCSC ID: uc011acy.2
RefSeq Accession: NM_181608
Protein: Q3LHN2 (aka KR192_HUMAN)
CCDS: CCDS13595.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_181608.1
exon count: 1CDS single in 3' UTR: no RNA size: 159
ORF size: 159CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 419.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.