Description: Homo sapiens Kruppel-like factor 14 (KLF14), mRNA. RefSeq Summary (NM_138693): This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chr7:130,417,396-130,418,888 Size: 1,493 Total Exon Count: 1 Strand: - Coding Region Position: hg19 chr7:130,417,889-130,418,860 Size: 972 Coding Exon Count: 1
Cholesterol, HDL Tanya M Teslovich et al. Nature 2010, Biological, clinical and population relevance of 95 loci for blood lipids., Nature.
[PubMed 20686565]
Diabetes Mellitus, Type 2 Benjamin F Voight et al. Nature genetics 2010, Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis., Nature genetics.
[PubMed 20581827]
Common Gene Haplotype Alleles
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Microarray Expression Data
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TD94
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
