Description: Homo sapiens interferon (alpha, beta and omega) receptor 2 (IFNAR2), transcript variant 1, mRNA. RefSeq Summary (NM_207585): The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]. Transcript (Including UTRs) Position: hg19 chr21:34,602,231-34,636,820 Size: 34,590 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr21:34,614,228-34,635,805 Size: 21,578 Coding Exon Count: 8
ID:INAR2_HUMAN DESCRIPTION: RecName: Full=Interferon alpha/beta receptor 2; Short=IFN-R-2; Short=IFN-alpha binding protein; Short=IFN-alpha/beta receptor 2; AltName: Full=Interferon alpha binding protein; AltName: Full=Type I interferon receptor 2; Flags: Precursor; FUNCTION: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. SUBUNIT: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. INTERACTION: Q92793:CREBBP; NbExp=4; IntAct=EBI-958408, EBI-81215; P63244:GNB2L1; NbExp=4; IntAct=EBI-958408, EBI-296739; Q00978:IRF9; NbExp=6; IntAct=EBI-958408, EBI-626526; P52630:STAT2; NbExp=2; IntAct=EBI-958408, EBI-1546963; SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 3: Secreted. TISSUE SPECIFICITY: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. PTM: Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types. PTM: Glycosylated. POLYMORPHISM: Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]. SIMILARITY: Belongs to the type II cytokine receptor family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ifnar2/";
respiratory syncytial virus bronchiolitis Christine L E Siezen , et al. The Pediatric infectious disease journal 2009 28(4):333-5, Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes., The Pediatric infectious disease journal 2009 28(4):333-5.
[PubMed 19258923]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48551
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004905 type I interferon receptor activity GO:0005515 protein binding GO:0019901 protein kinase binding GO:0019962 type I interferon binding
Biological Process: GO:0007166 cell surface receptor signaling pathway GO:0007259 JAK-STAT cascade GO:0009615 response to virus GO:0035455 response to interferon-alpha GO:0035456 response to interferon-beta GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
