Description: Homo sapiens interleukin 10 receptor, alpha (IL10RA), transcript variant 1, mRNA. RefSeq Summary (NM_001558): The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]. Transcript (Including UTRs) Position: hg19 chr11:117,857,106-117,872,199 Size: 15,094 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr11:117,857,183-117,870,356 Size: 13,174 Coding Exon Count: 7
ID:I10R1_HUMAN DESCRIPTION: RecName: Full=Interleukin-10 receptor subunit alpha; Short=IL-10 receptor subunit alpha; Short=IL-10R subunit alpha; Short=IL-10RA; AltName: Full=CDw210a; AltName: Full=Interleukin-10 receptor subunit 1; Short=IL-10R subunit 1; Short=IL-10R1; AltName: CD_antigen=CD210; Flags: Precursor; FUNCTION: Receptor for IL10; binds IL10 with a high affinity. INTERACTION: P03180:BCRF1 (xeno); NbExp=2; IntAct=EBI-1031656, EBI-1042167; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels. DISEASE: Defects in IL10RA are the cause of inflammatory bowel disease type 28 (IBD28) [MIM:613148]. It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. SIMILARITY: Belongs to the type II cytokine receptor family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il10ra/";
cirrhosis Hofer, H. et al. 2005, Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection., Genes and immunity. 2005 May;6(3):242-7.
[PubMed 15729365]
Our work implies that IL-10R1 SNP4 is a recessively inherited risk factor for hepatic cirrhosis in HCV genotype-1 infection.
HIV Do, H. et al. 2006, Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort, Immunogenetics 2006.
[PubMed 16491350]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13651
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
