ID:IFNA7_HUMAN DESCRIPTION: RecName: Full=Interferon alpha-7; Short=IFN-alpha-7; AltName: Full=Interferon alpha-J; Short=LeIF J; AltName: Full=Interferon alpha-J1; Short=IFN-alpha-J1; Flags: Precursor; FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the alpha/beta interferon family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01567
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005132 type I interferon receptor binding
Biological Process: GO:0002250 adaptive immune response GO:0002286 T cell activation involved in immune response GO:0002323 natural killer cell activation involved in immune response GO:0006952 defense response GO:0006959 humoral immune response GO:0007267 cell-cell signaling GO:0007596 blood coagulation GO:0009615 response to virus GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0030183 B cell differentiation GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0042100 B cell proliferation GO:0043330 response to exogenous dsRNA GO:0045087 innate immune response GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
E00050 - DNA coding of LeIF H. V00542 - Messenger RNA for human leukocyte (alpha) interferon. KJ891432 - Synthetic construct Homo sapiens clone ccsbBroadEn_00826 IFNA7 gene, encodes complete protein. E00052 - DNA coding of LeIF J. LP896541 - Sequence 1405 from Patent EP3253886. M34913 - Human interferon-alpha-J1 (IFN-alpha-J1) mRNA, complete cds. JD052310 - Sequence 33334 from Patent EP1572962. BC113994 - Homo sapiens interferon, alpha 7, mRNA (cDNA clone MGC:138899 IMAGE:40084821), complete cds. BC114000 - Homo sapiens interferon, alpha 7, mRNA (cDNA clone MGC:138898 IMAGE:40084820), complete cds. JD249031 - Sequence 230055 from Patent EP1572962. JD249030 - Sequence 230054 from Patent EP1572962. BC074991 - Homo sapiens interferon, alpha 7, mRNA (cDNA clone MGC:104070 IMAGE:30915521), complete cds. BC074992 - Homo sapiens interferon, alpha 7, mRNA (cDNA clone MGC:103917 IMAGE:30915307), complete cds. A00149 - H.sapiens IFN-alpha-J1 mRNA. JD268678 - Sequence 249702 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
