To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): HSPA4 CDC HuGE Published Literature: HSPA4 Positive Disease Associations: preterm delivery Related Studies:
preterm delivery Kalish, R. B. et al. 2004, Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes., American journal of obstetrics and gynecology. 2004 Oct;191(4):1368-74.
[PubMed 15507967]
Tumor necrosis factor-alpha allele 2 and/or heat shock protein-70 allele 2 carriage by the first-born fetus is associated with preterm premature rupture of membranes in multifetal pregnancies.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P34932
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006986 response to unfolded protein GO:0045040 protein import into mitochondrial outer membrane GO:0051131 chaperone-mediated protein complex assembly
AB023420 - Homo sapiens mRNA for heat shock protein apg-2, complete cds. FJ224293 - Homo sapiens epididymis secretory sperm binding protein Li 5a (HEL-S-5a) mRNA, complete cds. BC126122 - Homo sapiens heat shock 70kDa protein 4, mRNA (cDNA clone MGC:161400 IMAGE:8991838), complete cds. BC126124 - Homo sapiens heat shock 70kDa protein 4, mRNA (cDNA clone MGC:161402 IMAGE:8991840), complete cds. AB209151 - Homo sapiens mRNA for heat shock 70kDa protein 4 isoform a variant protein. BC002526 - Homo sapiens heat shock 70kDa protein 4, mRNA (cDNA clone IMAGE:3139645), complete cds. AK294859 - Homo sapiens cDNA FLJ50510 complete cds, highly similar to Heat shock 70 kDa protein 4. BC110861 - Homo sapiens heat shock 70kDa protein 4, mRNA (cDNA clone MGC:131852 IMAGE:6169048), complete cds. L12723 - Homo sapiens heat shock protein 70 (hsp70) mRNA, complete cds. AK311097 - Homo sapiens cDNA, FLJ18139. X67643 - H.sapiens HS24/p52 mRNA. HQ258526 - Synthetic construct Homo sapiens clone IMAGE:100072955 heat shock 70kDa protein 4 (HSPA4) gene, encodes complete protein. KJ901498 - Synthetic construct Homo sapiens clone ccsbBroadEn_10892 HSPA4 gene, encodes complete protein. BT007375 - Homo sapiens heat shock protein, 110 kDa mRNA, complete cds. AK300770 - Homo sapiens cDNA FLJ50691 complete cds, highly similar to Heat shock 70 kDa protein 4. AK311483 - Homo sapiens cDNA, FLJ18525. AK295847 - Homo sapiens cDNA FLJ52593 complete cds, highly similar to Heat shock 70 kDa protein 4. AK311471 - Homo sapiens cDNA, FLJ18513. AK300050 - Homo sapiens cDNA FLJ54507 complete cds, highly similar to Heat shock 70 kDa protein 4. AK311224 - Homo sapiens cDNA, FLJ18266. AK311135 - Homo sapiens cDNA, FLJ18177. AK304578 - Homo sapiens cDNA FLJ55293 complete cds, highly similar to Heat shock 70 kDa protein 4. DL492554 - Novel nucleic acids. AK311299 - Homo sapiens cDNA, FLJ18341. AK303382 - Homo sapiens cDNA FLJ52584 complete cds, highly similar to Heat shock 70 kDa protein 4. AK311466 - Homo sapiens cDNA, FLJ18508. AK311615 - Homo sapiens cDNA, FLJ18657. AK311632 - Homo sapiens cDNA, FLJ18674. AB074275 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla10949, full insert sequence. AK311422 - Homo sapiens cDNA, FLJ18464. AK311465 - Homo sapiens cDNA, FLJ18507. AK311125 - Homo sapiens cDNA, FLJ18167. AK311457 - Homo sapiens cDNA, FLJ18499. AK299710 - Homo sapiens cDNA FLJ50643 complete cds, highly similar to Heat shock 70 kDa protein 4. AK315887 - Homo sapiens cDNA, FLJ79536 complete cds, highly similar to Heat shock 70 kDa protein 4. AK311316 - Homo sapiens cDNA, FLJ18358. AK315862 - Homo sapiens cDNA, FLJ79511 complete cds, highly similar to Heat shock 70 kDa protein 4. AK315871 - Homo sapiens cDNA, FLJ79520 complete cds, highly similar to Heat shock 70 kDa protein 4. AK315875 - Homo sapiens cDNA, FLJ79524 complete cds, highly similar to Heat shock 70 kDa protein 4. AK297762 - Homo sapiens cDNA FLJ50587 complete cds, highly similar to Heat shock 70 kDa protein 4. JD438719 - Sequence 419743 from Patent EP1572962. JD349862 - Sequence 330886 from Patent EP1572962. JD020093 - Sequence 1117 from Patent EP1572962. JD032753 - Sequence 13777 from Patent EP1572962. JD532581 - Sequence 513605 from Patent EP1572962. JD057655 - Sequence 38679 from Patent EP1572962. JD271933 - Sequence 252957 from Patent EP1572962. JD365901 - Sequence 346925 from Patent EP1572962. JD131518 - Sequence 112542 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04612 - Antigen processing and presentation
Reactome (by CSHL, EBI, and GO)
Protein P34932 (Reactome details) participates in the following event(s):
R-HSA-5251942 Hikeshi binds HSP70s:ATP R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli