Description: Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), transcript variant 3, mRNA. RefSeq Summary (NM_001271970): This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]. Transcript (Including UTRs) Position: hg19 chr6:44,213,903-44,221,625 Size: 7,723 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr6:44,216,367-44,221,335 Size: 4,969 Coding Exon Count: 11
ID:HS90B_HUMAN DESCRIPTION: RecName: Full=Heat shock protein HSP 90-beta; Short=HSP 90; AltName: Full=Heat shock 84 kDa; Short=HSP 84; Short=HSP84; FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. SUBUNIT: Homodimer. Interacts with p53/TP53 (By similarity). Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7 (By similarity). Interacts with FKBP4. INTERACTION: P04049:RAF1; NbExp=2; IntAct=EBI-352572, EBI-365996; SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. DOMAIN: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro). PTM: ISGylated. PTM: S-nitrosylated; negatively regulates the ATPase activity (Probable). SIMILARITY: Belongs to the heat shock protein 90 family. SEQUENCE CAUTION: Sequence=AAD14062.3; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB66478.1; Type=Frameshift; Positions=709;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08238
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001890 placenta development GO:0006457 protein folding GO:0006805 xenobiotic metabolic process GO:0006950 response to stress GO:0006986 response to unfolded protein GO:0007004 telomere maintenance via telomerase GO:0009651 response to salt stress GO:0010033 response to organic substance GO:0019062 virion attachment to host cell GO:0021955 central nervous system neuron axonogenesis GO:0030010 establishment of cell polarity GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway GO:0031396 regulation of protein ubiquitination GO:0032092 positive regulation of protein binding GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032516 positive regulation of phosphoprotein phosphatase activity GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033160 positive regulation of protein import into nucleus, translocation GO:0035690 cellular response to drug GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0042220 response to cocaine GO:0042493 response to drug GO:0043066 negative regulation of apoptotic process GO:0043312 neutrophil degranulation GO:0043524 negative regulation of neuron apoptotic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045597 positive regulation of cell differentiation GO:0045793 positive regulation of cell size GO:0048675 axon extension GO:0050821 protein stabilization GO:0051131 chaperone-mediated protein complex assembly GO:0051248 negative regulation of protein metabolic process GO:0051897 positive regulation of protein kinase B signaling GO:0051973 positive regulation of telomerase activity GO:0060334 regulation of interferon-gamma-mediated signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0071157 negative regulation of cell cycle arrest GO:0071353 cellular response to interleukin-4 GO:0071407 cellular response to organic cyclic compound GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0097435 supramolecular fiber organization GO:1900034 regulation of cellular response to heat GO:1901389 negative regulation of transforming growth factor beta activation GO:1901799 negative regulation of proteasomal protein catabolic process GO:1902949 positive regulation of tau-protein kinase activity GO:1903660 negative regulation of complement-dependent cytotoxicity GO:1903827 regulation of cellular protein localization GO:1904031 positive regulation of cyclin-dependent protein kinase activity GO:1905323 telomerase holoenzyme complex assembly GO:2000010 positive regulation of protein localization to cell surface
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Common Gene Haplotype Alleles 
