Description: Homo sapiens G-protein signaling modulator 1 (GPSM1), transcript variant 1, mRNA. RefSeq Summary (NM_001145638): G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript (Including UTRs) Position: hg19 chr9:139,221,932-139,254,057 Size: 32,126 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chr9:139,222,152-139,252,672 Size: 30,521 Coding Exon Count: 14
ID:GPSM1_HUMAN DESCRIPTION: RecName: Full=G-protein-signaling modulator 1; AltName: Full=Activator of G-protein signaling 3; FUNCTION: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. SUBUNIT: Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. TISSUE SPECIFICITY: Expressed in intestinal cells. DOMAIN: The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha. PTM: Phosphorylation regulates interaction with G(i/o) alpha (By similarity). SIMILARITY: Belongs to the GPSM family. SIMILARITY: Contains 4 GoLoco domains. SIMILARITY: Contains 9 TPR repeats. SEQUENCE CAUTION: Sequence=AAH09979.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH17353.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB55951.1; Type=Frameshift; Positions=657; Sequence=CAI19339.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86YR5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
