Description: Homo sapiens guanine deaminase (GDA), transcript variant 1, mRNA. RefSeq Summary (NM_001242505): This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. Transcript (Including UTRs) Position: hg19 chr9:74,764,267-74,867,140 Size: 102,874 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr9:74,764,476-74,865,720 Size: 101,245 Coding Exon Count: 15
Suicidal Ideation N Perroud et al. The pharmacogenomics journal 2012, Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project., The pharmacogenomics journal.
[PubMed 20877300]
and replication in larger sample is warranted.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF01979 - Amidohydrolase family PF07969 - Amidohydrolase family
ModBase Predicted Comparative 3D Structure on Q9Y2T3-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.