Description: Homo sapiens growth arrest-specific 6 (GAS6), transcript variant 1, mRNA. RefSeq Summary (NM_000820): This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]. Transcript (Including UTRs) Position: hg19 chr13:114,523,522-114,567,046 Size: 43,525 Total Exon Count: 15 Strand: - Coding Region Position: hg19 chr13:114,523,837-114,566,893 Size: 43,057 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00054 - Laminin G domain PF00594 - Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain PF02210 - Laminin G domain PF07645 - Calcium-binding EGF domain PF12661 - Human growth factor-like EGF PF12662 - Complement Clr-like EGF-like PF14670 - Coagulation Factor Xa inhibitory site
ModBase Predicted Comparative 3D Structure on Q14393-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC038984 - Homo sapiens growth arrest-specific 6, mRNA (cDNA clone MGC:47731 IMAGE:5761791), complete cds. BC030708 - Homo sapiens cDNA clone IMAGE:4817801, containing frame-shift errors. L13720 - Homo sapiens growth-arrest-specific protein (gas) mRNA, complete cds. AK290803 - Homo sapiens cDNA FLJ76785 complete cds, highly similar to Homo sapiens growth arrest-specific 6 (GAS6), mRNA. KJ905201 - Synthetic construct Homo sapiens clone ccsbBroadEn_14653 GAS6-like gene, encodes complete protein. AL833761 - Homo sapiens mRNA; cDNA DKFZp666G247 (from clone DKFZp666G247). AK129751 - Homo sapiens cDNA FLJ26240 fis, clone DMC00611. AK092028 - Homo sapiens cDNA FLJ34709 fis, clone MESAN2003101, highly similar to Growth-arrest-specific protein 6 precursor. AK122969 - Homo sapiens cDNA FLJ16711 fis, clone UTERU2023045, highly similar to Growth-arrest-specific protein 6 precursor. AK126533 - Homo sapiens cDNA FLJ44569 fis, clone UTERU3009979, highly similar to Homo sapiens growth arrest-specific 6 (GAS6). AK303145 - Homo sapiens cDNA FLJ57022 complete cds, highly similar to Growth-arrest-specific protein 6 precursor. JD408074 - Sequence 389098 from Patent EP1572962. LF212189 - JP 2014500723-A/19692: Polycomb-Associated Non-Coding RNAs. JD317504 - Sequence 298528 from Patent EP1572962. JD187227 - Sequence 168251 from Patent EP1572962. JD187226 - Sequence 168250 from Patent EP1572962. JD404652 - Sequence 385676 from Patent EP1572962. JD458232 - Sequence 439256 from Patent EP1572962. MA447766 - JP 2018138019-A/19692: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q14393 (Reactome details) participates in the following event(s):
R-HSA-163810 GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) R-HSA-163843 Furin cleaves pro-GAS6 to GAS6 R-HSA-202710 MERTK receptor binds ligands (Gas6 or Protein S) R-HSA-481007 Exocytosis of platelet alpha granule contents R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159740 Gamma-carboxylation of protein precursors R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-114608 Platelet degranulation R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-109582 Hemostasis R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-597592 Post-translational protein modification R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
