Description: Homo sapiens forkhead box M1 (FOXM1), transcript variant 2, mRNA. RefSeq Summary (NM_021953): The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]. Transcript (Including UTRs) Position: hg19 chr12:2,966,847-2,986,321 Size: 19,475 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr12:2,967,804-2,983,644 Size: 15,841 Coding Exon Count: 8
ID:FOXM1_HUMAN DESCRIPTION: RecName: Full=Forkhead box protein M1; AltName: Full=Forkhead-related protein FKHL16; AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 11; Short=HFH-11; Short=HNF-3/fork-head homolog 11; AltName: Full=M-phase phosphoprotein 2; AltName: Full=MPM-2 reactive phosphoprotein 2; AltName: Full=Transcription factor Trident; AltName: Full=Winged-helix factor from INS-1 cells; FUNCTION: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. INTERACTION: Q00534:CDK6; NbExp=2; IntAct=EBI-866499, EBI-295663; P35222:CTNNB1; NbExp=16; IntAct=EBI-866480, EBI-491549; P03129:E7 (xeno); NbExp=3; IntAct=EBI-866499, EBI-866453; O43524:FOXO3; NbExp=2; IntAct=EBI-866480, EBI-1644164; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis. DEVELOPMENTAL STAGE: Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus. INDUCTION: Induced during liver regeneration and oxidative stress. DOMAIN: Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4. PTM: Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. SIMILARITY: Contains 1 fork-head DNA-binding domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FOXM1ID40631ch12p13.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/foxm1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08050
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0019901 protein kinase binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001558 regulation of cell growth GO:0006281 DNA repair GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006974 cellular response to DNA damage stimulus GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0007049 cell cycle GO:0008284 positive regulation of cell proliferation GO:0009653 anatomical structure morphogenesis GO:0030154 cell differentiation GO:0032873 negative regulation of stress-activated MAPK cascade GO:0042127 regulation of cell proliferation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046578 regulation of Ras protein signal transduction GO:0051726 regulation of cell cycle GO:0071156 regulation of cell cycle arrest GO:0090344 negative regulation of cell aging GO:2000377 regulation of reactive oxygen species metabolic process GO:2000781 positive regulation of double-strand break repair
US Server
