Description: Homo sapiens fatty acyl CoA reductase 2 (FAR2), transcript variant 1, mRNA. RefSeq Summary (NM_001271783): This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]. Transcript (Including UTRs) Position: hg19 chr12:29,301,936-29,488,549 Size: 186,614 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr12:29,423,383-29,486,727 Size: 63,345 Coding Exon Count: 11
ID:FACR2_HUMAN DESCRIPTION: RecName: Full=Fatty acyl-CoA reductase 2; EC=1.2.1.n2; AltName: Full=Male sterility domain-containing protein 1; FUNCTION: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. CATALYTIC ACTIVITY: Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH. SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein. SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01073 - 3-beta hydroxysteroid dehydrogenase/isomerase family PF01370 - NAD dependent epimerase/dehydratase family PF02719 - Polysaccharide biosynthesis protein PF03015 - Male sterility protein PF07993 - Male sterility protein
ModBase Predicted Comparative 3D Structure on Q96K12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0010025 wax biosynthetic process GO:0035336 long-chain fatty-acyl-CoA metabolic process GO:0055114 oxidation-reduction process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
