Human Gene DUSP22 (uc003msx.3)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: DUS22_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 22; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=JNK-stimulatory phosphatase-1; Short=JSP-1; AltName: Full=Low molecular weight dual specificity phosphatase 2; Short=LMW-DSP2; AltName: Full=Mitogen-activated protein kinase phosphatase x; Short=MAP kinase phosphatase x; Short=MKP-x;
FUNCTION: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity). CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas. PTM: Myristoylation regulates subcellular location, and is necessary for activation of JNK. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. SEQUENCE CAUTION: Sequence=AAH16844.1; Type=Erroneous initiation;
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Primer design for this transcript
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Genetic Association Studies of Complex Diseases and Disorders
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Genetic Association Database (archive): DUSP22
CDC HuGE Published Literature: DUSP22
Positive Disease Associations: Celiac Disease
Related Studies: - Celiac Disease
Patrick C A Dubois et al. Nature genetics 2010, Multiple common variants for celiac disease influencing immune gene expression., Nature genetics.
[PubMed 20190752]
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MalaCards Disease Associations
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Comparative Toxicogenomics Database (CTD)
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR020417 - Atypical_DUSP
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR000387 - Tyr/Dual-specificity_Pase
Pfam Domains: PF00782 - Dual specificity phosphatase, catalytic domain
SCOP Domains: 52799 - (Phosphotyrosine protein) phosphatases II
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9NRW4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AY249859 - Homo sapiens LMW-DSP2 mRNA, complete cds. BC022847 - Homo sapiens dual specificity phosphatase 22, mRNA (cDNA clone MGC:15090 IMAGE:3942055), complete cds. JD478339 - Sequence 459363 from Patent EP1572962. JD485646 - Sequence 466670 from Patent EP1572962. AF424702 - Homo sapiens JNK-stimulating phosphatase 1 (JSP1) mRNA, complete cds. GQ901046 - Homo sapiens clone HEL-T-158 epididymis secretory sperm binding protein mRNA, complete cds. AK310653 - Homo sapiens cDNA, FLJ17695. JD110544 - Sequence 91568 from Patent EP1572962. AK296402 - Homo sapiens cDNA FLJ58846 complete cds, highly similar to Dual specificity protein phosphatase 22 (EC 3.1.3.48). AF165519 - Homo sapiens mitogen-activated protein kinase phosphatase x (MKPX) mRNA, complete cds. JD289168 - Sequence 270192 from Patent EP1572962. DQ896715 - Synthetic construct Homo sapiens clone IMAGE:100011175; FLH199374.01L; RZPDo839B1281D dual specificity phosphatase 22 (DUSP22) gene, encodes complete protein. DQ893393 - Synthetic construct clone IMAGE:100006023; FLH199468.01X; RZPDo839B1282D dual specificity phosphatase 22 (DUSP22) gene, encodes complete protein. AB528664 - Synthetic construct DNA, clone: pF1KB6802, Homo sapiens DUSP22 gene for dual specificity phosphatase 22, without stop codon, in Flexi system. CU692732 - Synthetic construct Homo sapiens gateway clone IMAGE:100021866 5' read DUSP22 mRNA. KJ894364 - Synthetic construct Homo sapiens clone ccsbBroadEn_03758 DUSP22 gene, encodes complete protein. AK093183 - Homo sapiens cDNA FLJ35864 fis, clone TESTI2007657, highly similar to Dual specificity protein phosphatase 22 (EC 3.1.3.48). AX747976 - Sequence 1501 from Patent EP1308459. AK128760 - Homo sapiens cDNA FLJ45042 fis, clone BRAWH3020928, moderately similar to Homo sapiens mitogen-activated protein kinase phosphatase x (MKPX). AB208997 - Homo sapiens mRNA for dual specificity phosphatase 22 variant protein. BX648953 - Homo sapiens mRNA; cDNA DKFZp686I1848 (from clone DKFZp686I1848). AK000383 - Homo sapiens cDNA FLJ20376 fis, clone HUV01087. AK074410 - Homo sapiens cDNA FLJ23830 fis, clone HUV01083. BC016844 - Homo sapiens dual specificity phosphatase 22, mRNA (cDNA clone IMAGE:3905407), complete cds. DQ574629 - Homo sapiens piRNA piR-42741, complete sequence. KJ899276 - Synthetic construct Homo sapiens clone ccsbBroadEn_08670 DUSP22 gene, encodes complete protein. DQ588719 - Homo sapiens piRNA piR-55831, complete sequence. JD304699 - Sequence 285723 from Patent EP1572962. JD320652 - Sequence 301676 from Patent EP1572962. JD125555 - Sequence 106579 from Patent EP1572962.
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Other Names for This Gene
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Alternate Gene Symbols: B4DK56, DUS22_HUMAN, JSP1, LMWDSP2, MKPX, NM_020185, NP_064570, Q59GW2, Q5VWR2, Q96AR1, Q9NRW4 UCSC ID: uc003msx.3 RefSeq Accession: NM_020185
Protein: Q9NRW4
(aka DUS22_HUMAN)
CCDS: CCDS4468.1
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Gene Model Information
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category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_020185.3
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exon count:
| 8 | CDS single in 3' UTR:
| no
| RNA size:
| 1511 |
ORF size:
| 555 | CDS single in intron:
| no
| Alignment % ID:
| 99.87 |
txCdsPredict score:
| 1301.00 | frame shift in genome:
| no
| % Coverage:
| 98.01 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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