Human Gene DUSP22 (uc003msx.3)
  Description: Homo sapiens dual specificity phosphatase 22 (DUSP22), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:292,101-351,355 Size: 59,255 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr6:292,540-350,868 Size: 58,329 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:292,101-351,355)mRNA (may differ from genome)Protein (184 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DUS22_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 22; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=JNK-stimulatory phosphatase-1; Short=JSP-1; AltName: Full=Low molecular weight dual specificity phosphatase 2; Short=LMW-DSP2; AltName: Full=Mitogen-activated protein kinase phosphatase x; Short=MAP kinase phosphatase x; Short=MKP-x;
FUNCTION: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity).
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
TISSUE SPECIFICITY: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.
PTM: Myristoylation regulates subcellular location, and is necessary for activation of JNK.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
SEQUENCE CAUTION: Sequence=AAH16844.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DUSP22
CDC HuGE Published Literature: DUSP22
Positive Disease Associations: Celiac Disease
Related Studies:
  1. Celiac Disease
    Patrick C A Dubois et al. Nature genetics 2010, Multiple common variants for celiac disease influencing immune gene expression., Nature genetics. [PubMed 20190752]

-  MalaCards Disease Associations
  MalaCards Gene Search: DUSP22
Diseases sorted by gene-association score: alk-negative anaplastic large cell lymphoma (13), lymphatic system cancer (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.73 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 566.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -237.90439-0.542 Picture PostScript Text
3' UTR -136.50487-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020417 - Atypical_DUSP
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR000387 - Tyr/Dual-specificity_Pase

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1WRM - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9NRW4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000188 inactivation of MAPK activity
GO:0002710 negative regulation of T cell mediated immunity
GO:0006470 protein dephosphorylation
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organism development
GO:0008283 cell proliferation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042127 regulation of cell proliferation
GO:0046330 positive regulation of JNK cascade
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AY249859 - Homo sapiens LMW-DSP2 mRNA, complete cds.
BC022847 - Homo sapiens dual specificity phosphatase 22, mRNA (cDNA clone MGC:15090 IMAGE:3942055), complete cds.
JD478339 - Sequence 459363 from Patent EP1572962.
JD485646 - Sequence 466670 from Patent EP1572962.
AF424702 - Homo sapiens JNK-stimulating phosphatase 1 (JSP1) mRNA, complete cds.
GQ901046 - Homo sapiens clone HEL-T-158 epididymis secretory sperm binding protein mRNA, complete cds.
AK310653 - Homo sapiens cDNA, FLJ17695.
JD110544 - Sequence 91568 from Patent EP1572962.
AK296402 - Homo sapiens cDNA FLJ58846 complete cds, highly similar to Dual specificity protein phosphatase 22 (EC 3.1.3.48).
AF165519 - Homo sapiens mitogen-activated protein kinase phosphatase x (MKPX) mRNA, complete cds.
JD289168 - Sequence 270192 from Patent EP1572962.
DQ896715 - Synthetic construct Homo sapiens clone IMAGE:100011175; FLH199374.01L; RZPDo839B1281D dual specificity phosphatase 22 (DUSP22) gene, encodes complete protein.
DQ893393 - Synthetic construct clone IMAGE:100006023; FLH199468.01X; RZPDo839B1282D dual specificity phosphatase 22 (DUSP22) gene, encodes complete protein.
AB528664 - Synthetic construct DNA, clone: pF1KB6802, Homo sapiens DUSP22 gene for dual specificity phosphatase 22, without stop codon, in Flexi system.
CU692732 - Synthetic construct Homo sapiens gateway clone IMAGE:100021866 5' read DUSP22 mRNA.
KJ894364 - Synthetic construct Homo sapiens clone ccsbBroadEn_03758 DUSP22 gene, encodes complete protein.
AK093183 - Homo sapiens cDNA FLJ35864 fis, clone TESTI2007657, highly similar to Dual specificity protein phosphatase 22 (EC 3.1.3.48).
AX747976 - Sequence 1501 from Patent EP1308459.
AK128760 - Homo sapiens cDNA FLJ45042 fis, clone BRAWH3020928, moderately similar to Homo sapiens mitogen-activated protein kinase phosphatase x (MKPX).
AB208997 - Homo sapiens mRNA for dual specificity phosphatase 22 variant protein.
BX648953 - Homo sapiens mRNA; cDNA DKFZp686I1848 (from clone DKFZp686I1848).
AK000383 - Homo sapiens cDNA FLJ20376 fis, clone HUV01087.
AK074410 - Homo sapiens cDNA FLJ23830 fis, clone HUV01083.
BC016844 - Homo sapiens dual specificity phosphatase 22, mRNA (cDNA clone IMAGE:3905407), complete cds.
DQ574629 - Homo sapiens piRNA piR-42741, complete sequence.
KJ899276 - Synthetic construct Homo sapiens clone ccsbBroadEn_08670 DUSP22 gene, encodes complete protein.
DQ588719 - Homo sapiens piRNA piR-55831, complete sequence.
JD304699 - Sequence 285723 from Patent EP1572962.
JD320652 - Sequence 301676 from Patent EP1572962.
JD125555 - Sequence 106579 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DK56, DUS22_HUMAN, JSP1, LMWDSP2, MKPX, NM_020185, NP_064570, Q59GW2, Q5VWR2, Q96AR1, Q9NRW4
UCSC ID: uc003msx.3
RefSeq Accession: NM_020185
Protein: Q9NRW4 (aka DUS22_HUMAN)
CCDS: CCDS4468.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020185.3
exon count: 8CDS single in 3' UTR: no RNA size: 1511
ORF size: 555CDS single in intron: no Alignment % ID: 99.87
txCdsPredict score: 1301.00frame shift in genome: no % Coverage: 98.01
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.