Description: Homo sapiens casein beta (CSN2), mRNA. RefSeq Summary (NM_001891): This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. Transcript (Including UTRs) Position: hg19 chr4:70,820,974-70,826,726 Size: 5,753 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr4:70,822,068-70,826,713 Size: 4,646 Coding Exon Count: 6
ID:CASB_HUMAN DESCRIPTION: RecName: Full=Beta-casein; Flags: Precursor; FUNCTION: Important role in determination of the surface properties of the casein micelles. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk. PTM: Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25. SIMILARITY: Belongs to the beta-casein family. WEB RESOURCE: Name=Protein Spotlight; Note=Of buttons, digestion and glue - Issue 16 of November 2001; URL="http://web.expasy.org/spotlight/back_issues/sptlt016.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05814
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006816 calcium ion transport GO:0007595 lactation GO:1903488 negative regulation of lactation GO:2000117 negative regulation of cysteine-type endopeptidase activity
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
A30262 - H.sapiens beta-casein cDNA. X55739 - Homo sapiens mRNA for beta-casein. X13766 - Human beta-casein mRNA 3'-terminal fragment. X17070 - Human mRNA for beta-casein. JD562817 - Sequence 543841 from Patent EP1572962. BC096194 - Homo sapiens casein beta, mRNA (cDNA clone MGC:116846 IMAGE:40004178), complete cds. BC096196 - Homo sapiens casein beta, mRNA (cDNA clone MGC:116848 IMAGE:40004180), complete cds. BC096197 - Homo sapiens casein beta, mRNA (cDNA clone MGC:116849 IMAGE:40004181), complete cds. BC069554 - Homo sapiens casein beta, mRNA (cDNA clone MGC:96987 IMAGE:7262196), complete cds. BC096195 - Homo sapiens casein beta, mRNA (cDNA clone MGC:116847 IMAGE:40004179), complete cds. JD551026 - Sequence 532050 from Patent EP1572962. KF751868 - Homo sapiens casein beta mRNA, complete cds. KJ890983 - Synthetic construct Homo sapiens clone ccsbBroadEn_00377 CSN2 gene, encodes complete protein. JD204304 - Sequence 185328 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P05814 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
