Description: Homo sapiens CAP-GLY domain containing linker protein 1 (CLIP1), transcript variant 3, mRNA. RefSeq Summary (NM_001247997): The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: hg19 chr12:122,755,981-122,907,116 Size: 151,136 Total Exon Count: 26 Strand: - Coding Region Position: hg19 chr12:122,757,422-122,864,999 Size: 107,578 Coding Exon Count: 25
ID:CLIP1_HUMAN DESCRIPTION: RecName: Full=CAP-Gly domain-containing linker protein 1; AltName: Full=Cytoplasmic linker protein 1; AltName: Full=Cytoplasmic linker protein 170 alpha-2; Short=CLIP-170; AltName: Full=Reed-Sternberg intermediate filament-associated protein; AltName: Full=Restin; FUNCTION: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. SUBUNIT: Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles. TISSUE SPECIFICITY: Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. DOMAIN: Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin. PTM: Phosphorylated. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules. SIMILARITY: Contains 2 CAP-Gly domains. SIMILARITY: Contains 1 CCHC-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30622
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB209115 - Homo sapiens mRNA for restin isoform a variant protein. A21860 - H.sapiens MRP-160 mRNA. X64838 - H.sapiens mRNA for restin. AK126990 - Homo sapiens cDNA FLJ45045 fis, clone BRAWH3021580, highly similar to Restin (Cytoplasmic linker protein 170 alpha-2). M97501 - Human cytoplasmic linker protein-170 alpha-2 (CLIP-170) mRNA, complete cds. BC117209 - Homo sapiens CAP-GLY domain containing linker protein 1, mRNA (cDNA clone MGC:150818 IMAGE:40125760), complete cds. BC126305 - Homo sapiens CAP-GLY domain containing linker protein 1, mRNA (cDNA clone MGC:161583 IMAGE:8992021), complete cds. BC114213 - Homo sapiens CAP-GLY domain containing linker protein 1, mRNA (cDNA clone MGC:131604 IMAGE:7961952), complete cds. JD183397 - Sequence 164421 from Patent EP1572962. JD082561 - Sequence 63585 from Patent EP1572962. JD304343 - Sequence 285367 from Patent EP1572962. JD236266 - Sequence 217290 from Patent EP1572962. JD040375 - Sequence 21399 from Patent EP1572962. JD564908 - Sequence 545932 from Patent EP1572962. JD553471 - Sequence 534495 from Patent EP1572962. JD296566 - Sequence 277590 from Patent EP1572962. JD230301 - Sequence 211325 from Patent EP1572962. JD288325 - Sequence 269349 from Patent EP1572962. JD389710 - Sequence 370734 from Patent EP1572962. JD050888 - Sequence 31912 from Patent EP1572962. JD149767 - Sequence 130791 from Patent EP1572962. JD460106 - Sequence 441130 from Patent EP1572962. JD310342 - Sequence 291366 from Patent EP1572962. JD402807 - Sequence 383831 from Patent EP1572962. AK123769 - Homo sapiens cDNA FLJ41775 fis, clone IMR322012314. BC062543 - Homo sapiens CAP-GLY domain containing linker protein 1, mRNA (cDNA clone IMAGE:5921093), partial cds. AY563000 - Homo sapiens restin isoform b (RSN) mRNA, partial cds, alternatively spliced. AF045653 - Homo sapiens cytoplasmic linker protein CLIP-170 mRNA, CLIP(11+35) isoform, partial cds. AF045652 - Homo sapiens cytoplasmic linker protein CLIP-170 mRNA, CLIP-170(11) isoform, partial cds. BC047895 - Homo sapiens CAP-GLY domain containing linker protein 1, mRNA (cDNA clone IMAGE:5742243), partial cds. BC039081 - Homo sapiens CAP-GLY domain containing linker protein 1, mRNA (cDNA clone IMAGE:5166086), with apparent retained intron. KJ905913 - Synthetic construct Homo sapiens clone ccsbBroadEn_15583 CLIP1 gene, encodes complete protein. CU691656 - Synthetic construct Homo sapiens gateway clone IMAGE:100022626 5' read CLIP1 mRNA. JD185039 - Sequence 166063 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_Lis1Pathway - Lissencephaly gene (LIS1) in neuronal migration and development
Reactome (by CSHL, EBI, and GO)
Protein P30622 (Reactome details) participates in the following event(s):
R-HSA-5672329 IQGAP1 binds CLIP1 and microtubules R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-5626467 RHO GTPases activate IQGAPs R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-195258 RHO GTPase Effectors R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-194315 Signaling by Rho GTPases R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-162582 Signal Transduction R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle
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