Description: Homo sapiens cell division cycle 7 (CDC7), transcript variant 2, mRNA. RefSeq Summary (NM_001134419): This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]. Transcript (Including UTRs) Position: hg19 chr1:91,966,404-91,991,321 Size: 24,918 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr1:91,967,274-91,989,992 Size: 22,719 Coding Exon Count: 11
ID:CDC7_HUMAN DESCRIPTION: RecName: Full=Cell division cycle 7-related protein kinase; Short=CDC7-related kinase; Short=HsCdc7; Short=huCdc7; EC=2.7.11.1; FUNCTION: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. SUBUNIT: Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. SIMILARITY: Contains 1 protein kinase domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc7/";
Blood Pressure Daniel Levy et al. BMC medical genetics 2007, Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness., BMC medical genetics.
[PubMed 17903302]
These results of genome-wide association testing for blood pressure and arterial stiffness phenotypes in an unselected community-based sample of adults may aid in the identification of the genetic basis of hypertension and arterial disease, help identify high risk individuals, and guide novel therapies for hypertension. Additional studies are needed to replicate any associations identified in these analyses.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on O00311
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
AK298963 - Homo sapiens cDNA FLJ51946 complete cds, highly similar to Cell division cycle 7-related protein kinase (EC 2.7.11.1). BC111044 - Homo sapiens cell division cycle 7 homolog (S. cerevisiae), mRNA (cDNA clone MGC:117361 IMAGE:5518616), complete cds. GQ900903 - Homo sapiens clone HEL-T-15 epididymis secretory sperm binding protein mRNA, complete cds. AB209337 - Homo sapiens mRNA for CDC7 cell division cycle 7 variant protein. AF015592 - Homo sapiens Cdc7 (CDC7) mRNA, complete cds. BC110526 - Homo sapiens cell division cycle 7 homolog (S. cerevisiae), mRNA (cDNA clone MGC:126237 IMAGE:40034178), complete cds. BC110527 - Homo sapiens cell division cycle 7 homolog (S. cerevisiae), mRNA (cDNA clone MGC:126238 IMAGE:40034179), complete cds. AB003698 - Homo sapiens mRNA for Cdc7-related kinase, complete cds. JD439464 - Sequence 420488 from Patent EP1572962. AK312726 - Homo sapiens cDNA, FLJ93132, highly similar to Homo sapiens CDC7 cell division cycle 7 (S. cerevisiae) (CDC7), mRNA. AB590547 - Synthetic construct DNA, clone: pFN21AE0979, Homo sapiens CDC7 gene for cell division cycle 7 homolog, without stop codon, in Flexi system. KJ897825 - Synthetic construct Homo sapiens clone ccsbBroadEn_07219 CDC7 gene, encodes complete protein. AF005209 - Homo sapiens HsCdc7 mRNA, complete cds. AY312583 - Homo sapiens cell division cycle 7-like protein 1 (CDC7) mRNA, partial cds, alternatively spliced. JD237829 - Sequence 218853 from Patent EP1572962. JD503323 - Sequence 484347 from Patent EP1572962. JD291896 - Sequence 272920 from Patent EP1572962. JD181307 - Sequence 162331 from Patent EP1572962. JD552012 - Sequence 533036 from Patent EP1572962. JD294515 - Sequence 275539 from Patent EP1572962. JD528395 - Sequence 509419 from Patent EP1572962. JD060602 - Sequence 41626 from Patent EP1572962. JD276498 - Sequence 257522 from Patent EP1572962. JD164260 - Sequence 145284 from Patent EP1572962. JD168449 - Sequence 149473 from Patent EP1572962. JD314641 - Sequence 295665 from Patent EP1572962. JD176612 - Sequence 157636 from Patent EP1572962. JD170816 - Sequence 151840 from Patent EP1572962. JD208154 - Sequence 189178 from Patent EP1572962. JD225763 - Sequence 206787 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04110 - Cell cycle
Reactome (by CSHL, EBI, and GO)
Protein O00311 (Reactome details) participates in the following event(s):
R-HSA-68918 CDK and DDK associate with the Mcm10:pre-replicative complex R-HSA-68917 Cdc45 associates with the pre-replicative complex at the origin R-HSA-68954 Mcm2-7 is phosphorylated by DDK R-HSA-68916 DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin R-HSA-176318 Loading of claspin onto DNA during replication origin firing R-HSA-176298 Activation of claspin R-HSA-8953750 Transcriptional Regulation by E2F6 R-HSA-68962 Activation of the pre-replicative complex R-HSA-212436 Generic Transcription Pathway R-HSA-69002 DNA Replication Pre-Initiation R-HSA-69206 G1/S Transition R-HSA-73857 RNA Polymerase II Transcription R-HSA-176187 Activation of ATR in response to replication stress R-HSA-68874 M/G1 Transition R-HSA-453279 Mitotic G1-G1/S phases R-HSA-74160 Gene expression (Transcription) R-HSA-69481 G2/M Checkpoints R-HSA-69278 Cell Cycle (Mitotic) R-HSA-69306 DNA Replication R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle