Description: Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_004052): This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]. Transcript (Including UTRs) Position: hg19 chr10:133,781,204-133,795,435 Size: 14,232 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr10:133,782,028-133,795,310 Size: 13,283 Coding Exon Count: 6
ID:BNIP3_HUMAN DESCRIPTION: RecName: Full=BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; FUNCTION: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. SUBUNIT: Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). INTERACTION: Self; NbExp=2; IntAct=EBI-749464, EBI-749464; O60238:BNIP3L; NbExp=8; IntAct=EBI-749464, EBI-849893; O60313:OPA1; NbExp=10; IntAct=EBI-749464, EBI-1054131; P17152:TMEM11; NbExp=2; IntAct=EBI-749464, EBI-723946; SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane. SIMILARITY: Belongs to the NIP3 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BNIP3ID822ch10q26.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bnip3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12983
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity GO:0051020 GTPase binding
Biological Process: GO:0000422 mitophagy GO:0001666 response to hypoxia GO:0006915 apoptotic process GO:0008219 cell death GO:0008626 granzyme-mediated apoptotic signaling pathway GO:0010508 positive regulation of autophagy GO:0010637 negative regulation of mitochondrial fusion GO:0010659 cardiac muscle cell apoptotic process GO:0010666 positive regulation of cardiac muscle cell apoptotic process GO:0010821 regulation of mitochondrion organization GO:0010917 negative regulation of mitochondrial membrane potential GO:0010940 positive regulation of necrotic cell death GO:0016032 viral process GO:0016239 positive regulation of macroautophagy GO:0021987 cerebral cortex development GO:0035694 mitochondrial protein catabolic process GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043068 positive regulation of programmed cell death GO:0043243 positive regulation of protein complex disassembly GO:0043653 mitochondrial fragmentation involved in apoptotic process GO:0045837 negative regulation of membrane potential GO:0046902 regulation of mitochondrial membrane permeability GO:0048102 autophagic cell death GO:0048709 oligodendrocyte differentiation GO:0050873 brown fat cell differentiation GO:0051402 neuron apoptotic process GO:0051561 positive regulation of mitochondrial calcium ion concentration GO:0051607 defense response to virus GO:0055093 response to hyperoxia GO:0060548 negative regulation of cell death GO:0070301 cellular response to hydrogen peroxide GO:0071260 cellular response to mechanical stimulus GO:0071279 cellular response to cobalt ion GO:0071456 cellular response to hypoxia GO:0072593 reactive oxygen species metabolic process GO:0090141 positive regulation of mitochondrial fission GO:0090200 positive regulation of release of cytochrome c from mitochondria GO:0097193 intrinsic apoptotic signaling pathway GO:0097345 mitochondrial outer membrane permeabilization GO:1901998 toxin transport GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process GO:1903599 positive regulation of mitophagy GO:1903715 regulation of aerobic respiration GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia GO:2000378 negative regulation of reactive oxygen species metabolic process
US Server
