Description: Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA. RefSeq Summary (NM_000710): Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr14:96,722,547-96,731,100 Size: 8,554 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr14:96,730,020-96,731,081 Size: 1,062 Coding Exon Count: 1
ID:BKRB1_HUMAN DESCRIPTION: RecName: Full=B1 bradykinin receptor; Short=B1R; Short=BK-1 receptor; FUNCTION: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily. WEB RESOURCE: Name=Wikipedia; Note=Bradykinin receptor entry; URL="http://en.wikipedia.org/wiki/Bradykinin_receptor";
atherosclerosis, coronary Dhamrait, S. S. et al. 2003, Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension., European heart journal. 2003 Sep;24(18):1672-80.
[PubMed 14499231]
Common variation in the genes for the kinin B(1)and B(2)receptors influences prospective hypertensive coronary risk. These are the first reported human data to suggest a role for the B(1)R in human coronary vascular disease, and the first prospective study to demonstrate a similar role for the B(2)R.
hypertension Cui, J. et al. 2005, Sequence variation of bradykinin receptors B1 and B2 and association with hypertension., Journal of hypertension. 2005 Jan;23(1):55-62.
[PubMed 15643125]
These results support the hypothesis that the African-American population is an older population compared with the other samples and the two bradykinin receptors may play a role in blood pressure regulation.
hypertension Dhamrait SS 2003, Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension., European heart journal. 2003 Sep;24(18):1672-80.
[PubMed 14499231]
Common variation in the genes for the kinin B(1)and B(2)receptors influences prospective hypertensive coronary risk. These are the first reported human data to suggest a role for the B(1)R in human coronary vascular disease, and the first prospective study to demonstrate a similar role for the B(2)R.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P46663
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
