Description: Homo sapiens A kinase (PRKA) interacting protein 1 (AKIP1), transcript variant 1, mRNA. RefSeq Summary (NM_020642): This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: hg19 chr11:8,932,701-8,941,626 Size: 8,926 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr11:8,932,997-8,941,027 Size: 8,031 Coding Exon Count: 5
ID:AKIP1_HUMAN DESCRIPTION: RecName: Full=A-kinase-interacting protein 1; AltName: Full=Breast cancer-associated gene 3 protein; AltName: Full=PKA-interacting protein; AltName: Full=Proline-rich protein BCA3; FUNCTION: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. SUBUNIT: Interacts with PRKACA and RELA. INTERACTION: P17612:PRKACA; NbExp=4; IntAct=EBI-517035, EBI-476586; SUBCELLULAR LOCATION: Nucleus. Note=Locates to punctate spots. TISSUE SPECIFICITY: Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up- regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9NQ31
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
