Description: Homo sapiens adrenoceptor alpha 1A (ADRA1A), transcript variant 1, mRNA. RefSeq Summary (NM_000680): Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr8:26,627,222-26,722,922 Size: 95,701 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr8:26,627,666-26,722,486 Size: 94,821 Coding Exon Count: 2
ID:ADA1A_HUMAN DESCRIPTION: RecName: Full=Alpha-1A adrenergic receptor; AltName: Full=Alpha-1A adrenoreceptor; Short=Alpha-1A adrenoceptor; AltName: Full=Alpha-1C adrenergic receptor; AltName: Full=Alpha-adrenergic receptor 1c; FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. SUBUNIT: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. TISSUE SPECIFICITY: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethra and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. PTM: C-terminal Ser or Thr residues may be phosphorylated (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
hypertension Gu, D. et al. 2006, Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension, J Hypertens 2006 24(6) 1057-1064.
[PubMed 16685204]
Our findings suggest that the genetic variations in the ADRA1A gene are significantly associated with essential hypertension, and may play an important role in the development of essential hypertension in this Chinese population.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P35348
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004935 adrenergic receptor activity GO:0004937 alpha1-adrenergic receptor activity GO:0005515 protein binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0003084 positive regulation of systemic arterial blood pressure GO:0006915 apoptotic process GO:0006937 regulation of muscle contraction GO:0006939 smooth muscle contraction GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007267 cell-cell signaling GO:0007512 adult heart development GO:0007568 aging GO:0008285 negative regulation of cell proliferation GO:0009725 response to hormone GO:0010460 positive regulation of heart rate GO:0010507 negative regulation of autophagy GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0019229 regulation of vasoconstriction GO:0032230 positive regulation of synaptic transmission, GABAergic GO:0035024 negative regulation of Rho protein signal transduction GO:0035265 organ growth GO:0035556 intracellular signal transduction GO:0042493 response to drug GO:0043410 positive regulation of MAPK cascade GO:0045760 positive regulation of action potential GO:0045907 positive regulation of vasoconstriction GO:0045987 positive regulation of smooth muscle contraction GO:0055117 regulation of cardiac muscle contraction GO:0060073 micturition GO:0060402 calcium ion transport into cytosol GO:0060452 positive regulation of cardiac muscle contraction GO:0061049 cell growth involved in cardiac muscle cell development GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0090037 positive regulation of protein kinase C signaling GO:0097195 pilomotor reflex GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
