Description: Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), mRNA. RefSeq Summary (NM_004996): The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extend of this transcript is supported by transcript alignments. Transcript (Including UTRs) Position: hg19 chr16:16,043,434-16,236,930 Size: 193,497 Total Exon Count: 31 Strand: + Coding Region Position: hg19 chr16:16,043,609-16,235,138 Size: 191,530 Coding Exon Count: 31
ID:MRP1_HUMAN DESCRIPTION: RecName: Full=Multidrug resistance-associated protein 1; AltName: Full=ATP-binding cassette sub-family C member 1; AltName: Full=Leukotriene C(4) transporter; Short=LTC4 transporter; FUNCTION: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Lung, testis and peripheral blood mononuclear cells. SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. SIMILARITY: Contains 2 ABC transmembrane type-1 domains. SIMILARITY: Contains 2 ABC transporter domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MRPID106.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/abcc1/"; WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P33527";
cardiotoxicity, anthracycline-induced Wojnowski, L. et al. 2005, NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity, Circulation. 2005 Dec;112(24):3754-62.
[PubMed 16330681]
Genetic variants in doxorubicin transport and free radical metabolism may modulate the individual risk to develop ACT.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P33527
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa02010 - ABC transporters
BioCarta from NCI Cancer Genome Anatomy Project h_mrpPathway - Multi-Drug Resistance Factors
Reactome (by CSHL, EBI, and GO)
Protein P33527 (Reactome details) participates in the following event(s):
R-HSA-266070 LTC4 is exported from the cytosol by ABCC1 R-HSA-3095901 ABCC1 transports cytosolic Cbl to extracellular region R-HSA-1454916 The ABCC family mediates organic anion transport R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-382556 ABC-family proteins mediated transport R-HSA-2142753 Arachidonic acid metabolism R-HSA-196849 Metabolism of water-soluble vitamins and cofactors R-HSA-382551 Transport of small molecules R-HSA-8978868 Fatty acid metabolism R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
