the "Catalogue Of Somatic Mutations In Cancer," is an online database of somatic mutations found in
human cancer. Focused exclusively on non-inherited acquired mutations, COSMIC combines information
from a range of sources, curating the described relationships between cancer phenotypes and gene
(and genomic) mutations. These data are then made available in a number of ways including here in the
UCSC genome browser, on the COSMIC website with custom analytical tools, or via the
COSMIC sftp server.
Publications using COSMIC as a data source may cite our reference below.
The data in COSMIC are curated from a number of high-quality sources and combined into a single
resource. The sources include:
Information on known cancer genes, selected from the
Cancer Gene Census is curated manually to maximize its descriptive content.
UCSC was provided with the COSMIC annotations directly. The columns were reconfigured to match
our BED format, and 35 mutations were removed as they had illegal coordinates (start>stop).
The resulting file was converted to a bigBed for display using the bedToBigBed utility.
- Dense - Indicate the positions where COSMIC mutations have been annotated in a single horizontal
- Squish - Indicate each mutation, in vertical pileups where appropriate, while minimizing
screen space used.
- Pack - Indicate each mutation with Genomic Mutation ID (COSVnnnnn).
- Full - Show each mutation in detail, one per line, with Genomic Mutation ID (COSVnnnnn).
Clicking into any item also displays the reference allele, alternate allele, and the
Cosmic legacy mutation identifier (COSNnnnnn). Outlinks can also be found directly to COSMIC
for additional information.
The limited data available to UCSC can be explored interactively
with the Table Browser,
or the Data Integrator. For automated analysis, the data may be
queried from our REST API. Please refer to our
mailing list archives
for questions, or our Data Access FAQ for more
The complete data can be explored and downloaded via the COSMIC
For further information on COSMIC, or for help with the information provided, please contact
Forbes SA, Beare D, Boutselakis H, Bamford S, Bindal N, Tate J, Cole CG, Ward S, Dawson E, Ponting L
COSMIC: somatic cancer genetics at high-resolution.
Nucleic Acids Res. 2017 Jan 4;45(D1):D777-D783.
PMID: 27899578; PMC: PMC5210583