Description

This track indicates the mapped locations viewable in the MuPIT interactive system. Use the URL link MuPIT protein structures to enter the viewing system.

MuPIT interactive is a tool that allows you to map a sequence variant from its position in the human genome onto a protein structure. Viewing a variant on a protein structure can be useful in interpreting its potential biological consequences. After you have done the mapping, you can play with the protein structure by turning it around, zooming in and out, and turning color-coded annotations about the protein on and off.

Credits

A data mapping pipeline was developed in the Karchin lab to map from any genomic location to position in PDB structure(s).

• Noushin Niknafs
• Rachel Karchin
• Dewey Kim

In collaboration with:

• Mark Diekhans (UCSC)
• Jing Zhu (UCSC)
• David Haussler (UCSC)

The web server and visualization scripting was developed by In Silico Solutions:

• Rick Kim
• Michael Ryan
• Sean Ryan
• Gabriel Ritter

Funding:

• NIH 5U01CA180956-02
• NIH 3U24CA143858-2S1
• NIH 5R21CA152432-02

References

Niknafs N, Kim D, Kim R, Diekhans M, Ryan M, Stenson PD, Cooper DN, Karchin R. MuPIT interactive: webserver for mapping variant positions to annotated, interactive 3D structures. Hum Genet. 2013 Nov;132(11):1235-43. PMID: 23793516; PMC: PMC3797853