Gene interactions and pathways from curated databases and text-mining

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WNT11 — ZNRF3

Text-mined interactions from Literome

Hao et al., Nature 2012 (Colorectal Neoplasms...) : ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 ... Inhibition of ZNRF3 enhances Wnt/ß-catenin signalling and disrupts Wnt/planar cell polarity signalling in vivo
Koo et al., Nature 2012 (Adenoma...) : We conclude that RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation