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WNT11 — ZNRF3
Text-mined interactions from Literome
Hao et al., Nature 2012
(Colorectal Neoplasms...) :
ZNRF3 is associated with the Wnt receptor complex, and
inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 ... Inhibition of
ZNRF3 enhances Wnt/ß-catenin signalling and
disrupts Wnt/planar cell polarity signalling in vivo
Koo et al., Nature 2012
(Adenoma...) :
We conclude that RNF43 and
ZNRF3 reduce
Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation