Gene interactions and pathways from curated databases and text-mining

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CREB1 — XRCC5

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

McPhee et al., FEBS Lett 2000 : Challenge of Rat1 cells with rolipram alone was able to elicit the phosphorylation of CREB but not activation of either Rap1A or Rap1B
Zanassi et al., J Biol Chem 2001 : These results suggest that, in striatal neurons, intracellular Ca ( 2+ ) release, Rap1 , and ERK pathway play a crucial role in the PKA induced CREB phosphorylation and CREB dependent transcription