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AKT1 — XRCC5
Text-mined interactions from Literome
Tsygankova et al., Mol Cell Biol 2001
:
The ability of TSH to stimulate
Akt phosphorylation was markedly
enhanced by the expression of activated
Rap1A and was repressed in cells expressing a putative dominant negative Rap1A mutant ... Although the expression of activated
Rap1A was
sufficient to stimulate wortmannin-sensitive
Akt phosphorylation, TSH further increased Akt phosphorylation in a phosphatidylinositol 3-kinase- and PKA dependent manner
Wang et al., J Biol Chem 2001
:
Moreover, inhibition of
Rap1 by a Rap1 GTPase activating protein-1 also
resulted in a decrease in ERK and
Akt phosphorylation, which was not further decreased by cAMP, suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 ... The
role of
Rap1 in ERK and
Akt activity was further demonstrated by our observation that an active form of Epac, which activated Rap1 in the absence of cAMP, increased ERK and Akt phosphorylation
Grader-Beck et al., Blood 2003
:
Thus, TCR plus CD28 mediated activation of ERK1/2 and
PKB , cytokine production, and cell cycle progression, all of which are inhibited by cAMP,
require activation of Ras but not
Rap1
Dragoi et al., EMBO J 2005
:
Further in vitro analysis using purified DNA-PK and recombinant Akt proteins reveals that
DNA-PK directly
induces phosphorylation and activation of
Akt
Romano et al., Endocrinology 2006
:
Under the same conditions, PI3K and
Akt inhibition also both
increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein
Rap1 , which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Bozulic et al., Mol Cell 2008
:
PKB activation following DNA damage
requires 3-phosphoinositide dependent kinase 1 ( PDK1 ) and
DNA dependent protein kinase (DNA-PK)
Boehme et al., Proc Natl Acad Sci U S A 2008
:
Correspondingly, down-regulation of
DNA-PK prevented phosphorylation of
Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53 ... Correspondingly, down-regulation of
DNA-PK prevented phosphorylation of
Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53
Surucu et al., J Biol Chem 2008
:
However, the physiological
role of
DNA-PK in the regulation of
PKB phosphorylation remains to be established
Bozulic et al., Curr Opin Cell Biol 2009
(Neoplasms) :
This present review concerns
PKB regulation by mTORC2 and
DNA-PK in a stimulus dependent and context dependent manner and the possible implications of this for PKB activity, substrate specificity and therapeutic intervention
Edreira et al., J Biol Chem 2009
:
cAMP dependent protein kinase (PKA) mediated phosphorylation of
Rap1b is
required for cAMP dependent mitogenesis, tumorigenesis, and inhibition of
AKT activity
Mannell et al., Cell Signal 2010
:
The
DNA dependent protein kinase (DNA-PK) , long known for its importance in repairing DNA double strand breaks, belongs to the phosphatidylinositol-3 kinase (PI3-K) super family and has recently been identified as one of the enzymes phosphorylating and
activating Akt
Malchinkhuu et al., Mol Biol Cell 2009
(Glioma) :
The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is required for the inhibitory ISO induced and
Rap1B mediated
actions on the migration, Rac1 activation, and
Akt activation in response to LPA
Tawa et al., Circ Res 2010
(Disease Models, Animal...) :
Rap1 regulated the interaction between afadin and phosphatidylinositol 3-kinase (PI3K), recruitment of the afadin-PI3K complex to the leading edge, and the activation of
Akt , indicating the involvement of Rap1 and afadin in the PI3K-Akt signaling pathway
Zhang et al., Blood 2011
:
Moreover, increased
AKT ( Ser473 ) phosphorylation was observed in activated B cells, reminiscent of cancers treated with rapamycin, and was
reduced by a
DNA-pk inhibitor
Stronach et al., Neoplasia (New York, N.Y.) 2011
(Carcinoma...) :
DNA-PK mediates
AKT activation and apoptosis inhibition in clinically acquired platinum resistance ... Insulin mediated activation of AKT is unaffected by DNA-PK inhibitor treatment, suggesting that this effect is restricted to DNA damage mediated activation of AKT and that, clinically,
DNA-PK inhibition might
prevent platinum induced
AKT activation without interfering with normal glucose homeostasis, an unwanted toxicity of direct AKT inhibitors
Furusawa et al., Cancer Lett 2012
(Leukemia) :
Inhibition of ataxia-telangiectasia mutated (ATM) or DNA-PK revealed that
DNA-PK , rather than ATM, was preferentially
involved in
Akt phosphorylation and cell survival after US-exposure in all cell lines
Li et al., J Biol Chem 2013
:
Chemical inhibition of
DNA-PK , knockdown or deficiency of DNA-PK catalytic subunit (DNA-PKcs), or knock-out of the DNA-PK component Ku86
inhibited rapamycin induced
Akt phosphorylation ... Accordingly, simultaneous inhibition of mTOR and
DNA-PK did not
stimulate Akt activity and synergistically inhibited the growth of cancer cells both in vitro and in vivo