Gene interactions and pathways from curated databases and text-mining

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AKT1 — XRCC5

Text-mined interactions from Literome

Tsygankova et al., Mol Cell Biol 2001 : The ability of TSH to stimulate Akt phosphorylation was markedly enhanced by the expression of activated Rap1A and was repressed in cells expressing a putative dominant negative Rap1A mutant ... Although the expression of activated Rap1A was sufficient to stimulate wortmannin-sensitive Akt phosphorylation, TSH further increased Akt phosphorylation in a phosphatidylinositol 3-kinase- and PKA dependent manner
Wang et al., J Biol Chem 2001 : Moreover, inhibition of Rap1 by a Rap1 GTPase activating protein-1 also resulted in a decrease in ERK and Akt phosphorylation, which was not further decreased by cAMP, suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 ... The role of Rap1 in ERK and Akt activity was further demonstrated by our observation that an active form of Epac, which activated Rap1 in the absence of cAMP, increased ERK and Akt phosphorylation
Grader-Beck et al., Blood 2003 : Thus, TCR plus CD28 mediated activation of ERK1/2 and PKB , cytokine production, and cell cycle progression, all of which are inhibited by cAMP, require activation of Ras but not Rap1
Dragoi et al., EMBO J 2005 : Further in vitro analysis using purified DNA-PK and recombinant Akt proteins reveals that DNA-PK directly induces phosphorylation and activation of Akt
Romano et al., Endocrinology 2006 : Under the same conditions, PI3K and Akt inhibition also both increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein Rap1 , which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Bozulic et al., Mol Cell 2008 : PKB activation following DNA damage requires 3-phosphoinositide dependent kinase 1 ( PDK1 ) and DNA dependent protein kinase (DNA-PK)
Boehme et al., Proc Natl Acad Sci U S A 2008 : Correspondingly, down-regulation of DNA-PK prevented phosphorylation of Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53 ... Correspondingly, down-regulation of DNA-PK prevented phosphorylation of Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53
Surucu et al., J Biol Chem 2008 : However, the physiological role of DNA-PK in the regulation of PKB phosphorylation remains to be established
Bozulic et al., Curr Opin Cell Biol 2009 (Neoplasms) : This present review concerns PKB regulation by mTORC2 and DNA-PK in a stimulus dependent and context dependent manner and the possible implications of this for PKB activity, substrate specificity and therapeutic intervention
Edreira et al., J Biol Chem 2009 : cAMP dependent protein kinase (PKA) mediated phosphorylation of Rap1b is required for cAMP dependent mitogenesis, tumorigenesis, and inhibition of AKT activity
Mannell et al., Cell Signal 2010 : The DNA dependent protein kinase (DNA-PK) , long known for its importance in repairing DNA double strand breaks, belongs to the phosphatidylinositol-3 kinase (PI3-K) super family and has recently been identified as one of the enzymes phosphorylating and activating Akt
Malchinkhuu et al., Mol Biol Cell 2009 (Glioma) : The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is required for the inhibitory ISO induced and Rap1B mediated actions on the migration, Rac1 activation, and Akt activation in response to LPA
Tawa et al., Circ Res 2010 (Disease Models, Animal...) : Rap1 regulated the interaction between afadin and phosphatidylinositol 3-kinase (PI3K), recruitment of the afadin-PI3K complex to the leading edge, and the activation of Akt , indicating the involvement of Rap1 and afadin in the PI3K-Akt signaling pathway
Zhang et al., Blood 2011 : Moreover, increased AKT ( Ser473 ) phosphorylation was observed in activated B cells, reminiscent of cancers treated with rapamycin, and was reduced by a DNA-pk inhibitor
Stronach et al., Neoplasia (New York, N.Y.) 2011 (Carcinoma...) : DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance ... Insulin mediated activation of AKT is unaffected by DNA-PK inhibitor treatment, suggesting that this effect is restricted to DNA damage mediated activation of AKT and that, clinically, DNA-PK inhibition might prevent platinum induced AKT activation without interfering with normal glucose homeostasis, an unwanted toxicity of direct AKT inhibitors
Furusawa et al., Cancer Lett 2012 (Leukemia) : Inhibition of ataxia-telangiectasia mutated (ATM) or DNA-PK revealed that DNA-PK , rather than ATM, was preferentially involved in Akt phosphorylation and cell survival after US-exposure in all cell lines
Li et al., J Biol Chem 2013 : Chemical inhibition of DNA-PK , knockdown or deficiency of DNA-PK catalytic subunit (DNA-PKcs), or knock-out of the DNA-PK component Ku86 inhibited rapamycin induced Akt phosphorylation ... Accordingly, simultaneous inhibition of mTOR and DNA-PK did not stimulate Akt activity and synergistically inhibited the growth of cancer cells both in vitro and in vivo