Gene interactions and pathways from curated databases and text-mining

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CHUK — WNK1

Text-mined interactions from Literome

O'Mahony et al., J Biol Chem 2004 (Cell Transformation, Viral) : Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1 mediated phosphorylation of RelA/p65
Hoberg et al., Mol Cell Biol 2006 : Moreover, IKKalpha induced phosphorylation of RelA/p65 ( S536 ) displaces corepressor activity, allowing p300 mediated acetylation of RelA/p65 ... Introduction of nonphosphorylatable mutants of RelA/p65 and SMRT proteins or the inhibition of IKK activity results in active repression of NF-kappaB promoters by tethering the SMRT-HDAC3 complex
Singh et al., J Neurol Sci 2009 (Muscular Dystrophies) : The results indicate that increases in nuclear p65 activation in dystrophic muscle are not produced solely by increases in the activity of IkappaB-alpha kinase (IKK) , but are due primarily to increases in the expression of p65 and other NF-kappaB signaling components
Song et al., J Pharmacol Sci 2010 (MAP Kinase Signaling System) : The results showed that ruscogenin significantly suppressed p65 phosphorylation, IkappaB-alpha phosphorylation and degradation, and inhibited IkappaB kinase alpha (IKKalpha) and IKKbeta activation induced by TNF-alpha
Kar et al., Eur J Immunol 2011 (Inflammation...) : IKK induced the phosphorylation of p65 directly on Ser-536 residue whereas phosphorylation on Ser 276 residue was by sequential activation of Tpl-2/MEK/ERK/MSK1