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CREB1 — WDR61

Text-mined interactions from Literome

Melnikova et al., J Biol Chem 2006 (Melanoma...) : In metastatic melanoma cell lines, PAF induced CREB and ATF-1 phosphorylation via a PAFR mediated signal transduction mechanism that required pertussis toxin-insensitive Galphaq protein and adenylate cyclase activity and was antagonized by a cAMP dependent protein kinase A and p38 MAPK inhibitors ... PAF induced expression of pro-MMP-2 was causally related to PAF induced CREB and ATF-1 phosphorylation ; it was prevented by PAFR antagonist and inhibitors of p38 MAPK and protein kinase A and was abrogated upon quenching of CREB and ATF-1 activities by forced overexpression of a dominant negative form of CREB
Melnikova et al., Cancer Metastasis Rev 2007 (Inflammation...) : Furthermore, we showed that PAF stimulated the phosphorylation of CREB and ATF-1 in metastatic melanoma cells, which resulted in overexpression of MMP-2 and MT1-MMP
Melnikova et al., Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2008 : We have demonstrated that in metastatic melanoma cells, PAF stimulates the phosphorylation of cyclic adenosine monophosphate response element binding protein ( CREB ) and activating transcription factor 1 ( ATF-1 ), which results in overexpression of MMP-2 and membrane type 1-MMP ( membrane type 1-MMP )