Gene interactions and pathways from curated databases and text-mining

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AKT1 — VWF

Text-mined interactions from Literome

Mu et al., Blood 2008 : Deleting these, but not upstream sequences of GPIb alpha expressed in CHO cells, inhibited VWF/ristocetin dependent Akt phosphorylation, relative to wild-type receptor, confirming this region encompassed a functional PI3-kinase binding site
Zhang et al., Gastroenterology 2009 (Disease Models, Animal...) : Following CBDL, but not TAA exposure, rats developed HPS that was temporally correlated with increased numbers of lung microvessel ; increased levels of vWf , VE-cadherin and PCNA ; and activation of Akt and eNOS
Delaney et al., Arterioscler Thromb Vasc Biol 2012 : von Willebrand factor/GPIb-IX interaction sequentially activates the Src family kinase Lyn (SFK), phosphoinositide 3-kinase (PI3K), and Akt , leading to activation of integrin a ( IIb ) ß ( 3 ) and integrin dependent stable platelet adhesion and aggregation