Gene interactions and pathways from curated databases and text-mining

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IL12A — VIP

Text-mined interactions from Literome

Delgado et al., J Neuroimmunol 1999 (Endotoxemia) : VIP and PACAP inhibit IL-12 production in LPS stimulated macrophages ... Type 1 VIP receptor ( VPAC1 ), and to a lesser degree type 2 VIP receptor ( VPAC2 ), mediate the inhibition of IL-12 , primarily through the cAMP/PKA pathway ... VIP/PACAP inhibit the production of IL-12 , IL-6, tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma) in vivo in endotoxemic mice
Delneste et al., J Immunol 1999 : Among these neuropeptides, only VIP induces the production of bioactive IL-12 and the neoexpression of CD83 on a fraction of the DC population, with an effect significant at 100 and 10 nM, respectively ... In the presence of a suboptimal concentration of TNF-alpha, which has no detectable effect on DC by itself, VIP induces the production of high levels of bioactive IL-12 , the neoexpression of CD83 on almost all the DC population ( with an effect significant at 10 and 0.1 nM, respectively ), and the up-regulation of various adhesion and costimulatory molecule expression
Delgado et al., J Neuroimmunol 1999 : We reported previously that VIP and PACAP inhibit IL-6, IL-12 , TNF alpha and NO production, and enhance IL-10 production, from lipopolysaccharide (LPS) stimulated macrophages
Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha, interleukin (IL)-6, nitric oxide, and IL-12 ... VIP and PACAP inhibit IL-12 ( p40 ) gene expression by affecting both NF-kappaB binding and the composition of the Ets-2 binding complex
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit the production of TNF alpha, IL-6, IL-12 , and nitric oxide ( NO ), and stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells
Delgado et al., Biochem Biophys Res Commun 2003 : VIP was shown to inhibit IL-6, TNFalpha, IL-12 , chemokine, and nitric oxide production in endotoxin activated macrophages
Larocca et al., Int Immunopharmacol 2007 : VIP inhibited LPS induced TNF-alpha, IL-12 and nitrites accumulation in NOD macrophages while it increased IL-10 production
Xin et al., J Neuroimmunol 1998 : In this study, we investigated the effect of VIP on IL-12 , TNF alpha and nitric oxide ( NO ) production in macrophages following activation with lipopolysaccharide (LPS) or superantigens ... In vitro studies show that at physiologic concentrations, VIP inhibited IL-12 and NO but not TNF alpha production in macrophages which were stimulated with LPS or superantigens ... The inhibitory effect of VIP on IL-12 production appeared to be cAMP mediated since other cAMP inducing agents were also potent in inhibiting IL-12 production