Gene interactions and pathways from curated databases and text-mining

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CXCR4 — VHL

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CXCR4 → VHL (decreases, VHL Translocation)
    Evidence: CXCR4- induced cell-surface expression due to the loss of VHL function confers enhanced migratory potential to RCC cells in response to its cognate ligand stromal-derived factor 1 (SDF1).

Text-mined interactions from Literome

Staller et al., Nature 2003 (Adenocarcinoma, Clear Cell...) : Here we show that the von Hippel-Lindau tumour suppressor protein pVHL negatively regulates CXCR4 expression owing to its capacity to target hypoxia-inducible factor ( HIF ) for degradation under normoxic conditions
Struckmann et al., J Pathol 2008 (Carcinoma, Renal Cell...) : Our in vitro and in vivo data strongly indicate that pVHL coordinately regulates expression of metastasis associated genes CXCR4/CXCL12 and MMP2/MMP9 but the exact molecular mechanism of this regulation remains to be determined