◀ Back to CXCR4
CXCR4 — VHL
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CXCR4
→
VHL
(decreases, VHL Translocation)
Evidence: CXCR4- induced cell-surface expression due to the loss of VHL function confers enhanced migratory potential to RCC cells in response to its cognate ligand stromal-derived factor 1 (SDF1).
Text-mined interactions from Literome
Staller et al., Nature 2003
(Adenocarcinoma, Clear Cell...) :
Here we show that the von Hippel-Lindau tumour suppressor protein
pVHL negatively
regulates CXCR4 expression owing to its capacity to target hypoxia-inducible factor ( HIF ) for degradation under normoxic conditions
Struckmann et al., J Pathol 2008
(Carcinoma, Renal Cell...) :
Our in vitro and in vivo data strongly indicate that
pVHL coordinately
regulates expression of metastasis associated genes
CXCR4/CXCL12 and MMP2/MMP9 but the exact molecular mechanism of this regulation remains to be determined