◀ Back to TPO

TPO — VEGFA

Text-mined interactions from Literome

Kirito et al., Blood 2005 : Thus, we tested the hypothesis that TPO affects the autocrine production of VEGF to account for its favorable effects on HSCs ... We found that VEGF transcripts are reduced in purified sca-1 ( + ) /c-kit ( + ) /Gr-1 ( - ) marrow cells derived from Tpo ( -/- ) mice and that TPO induces VEGF transcripts in these primitive hematopoietic cells
Wang et al., Ann N Y Acad Sci 2005 : In addition, analysis of gene expression during hemangioblast development demonstrates that TPO is capable of increasing the mRNA expression of the VEGF receptor (VEGFR) and its own receptor ( c-mpl )
Kaushansky et al., Ann N Y Acad Sci 2005 : We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor
Kirito et al., Cell cycle (Georgetown, Tex.) 2005 : In recent studies we have shown that TPO stimulates production of vascular endothelial cell growth factor ( VEGF ), another cytokine vital for HSC physiology, promoting their survival and expansion into committed hematopoietic progenitors ... Like several other effects of the cytokine, the effect of TPO on VEGF expression is mediated by stabilization and activation of the primary transcription factor responsible for VEGF expression, the oxygen tension responsive hypoxia inducible factor-1 (HIF-1)
Bobik et al., FEBS Lett 1998 : In CMK cells TPO caused a time- and dose dependent increase in the levels of VEGF released into the medium ... In CD34+ haematopoietic progenitor cell cultures TPO stimulated VEGF mRNA expression and VEGF protein release ... These results demonstrate that TPO stimulates VEGF release in c-Mpl expressing cells and suggest that this process is an integral feature of the megakaryocytic differentiation programme