Skinner et al., J Biol Chem 2004
(Ovarian Neoplasms) :
HDM2 and p70S6K1 are two downstream targets of AKT that mediate growth factor induced VEGF transcriptional activation and HIF-1alpha expression
Zhou et al., Carcinogenesis 2007
(Neovascularization, Pathologic...) :
These results suggest that insulin induced HIF-1alpha and VEGF expression through H2O2 production and p70S6K1 activation in prostate cancer cells