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EPO — VEGFA
Text-mined interactions from Literome
Nitta et al., Eur J Pharmacol 1999
:
Recombinant human
erythropoietin stimulates
vascular endothelial growth factor release by glomerular endothelial cells ... We designed the present study to address the question of whether recombinant human
erythropoietin stimulates DNA synthesis and
vascular endothelial growth factor ( VEGF ) secretion in vitro using cultured bovine glomerular endothelial cells ( GENs )
Batra et al., Lab Invest 2003
(Neoplasms, Germ Cell and Embryonal...) :
Additionally, exogenous
erythropoietin increased production and secretion of angiogenic growth factors,
vascular endothelial growth factor , or placenta growth factor from the tumor cell lines, which promoted endothelial cell proliferation and chemotaxis
Tam et al., Nat Med 2006
(Polycythemia) :
High-grade inhibition of
VEGF induced hepatic synthesis of
erythropoietin ( Epo, encoded by Epo ) > 40-fold through a HIF-1alpha independent mechanism, in parallel with suppression of renal Epo mRNA
Sturiale et al., Ren Fail 2007
(Acute Kidney Injury...) :
Moreover,
EPO can mobilize stem cells and
increase the plasmatic levels and the renal expression of
VEGF
Wang et al., J Cereb Blood Flow Metab 2008
:
These in vitro results suggest that
EPO enhances
VEGF secretion in neural progenitor cells through activation of the PI3K/Akt and ERK1/2 signaling pathways and that neural progenitor cells treated with rhEPO upregulate VEGFR2 expression in cerebral endothelial cells, which along with VEGF secreted by neural progenitor cells promotes angiogenesis
Westenbrink et al., Cardiovasc Res 2010
(Disease Models, Animal...) :
We intended to delineate the mechanisms of
erythropoietin (EPO) induced cardiac
vascular endothelial growth factor ( VEGF ) production and to establish if VEGF is crucial for EPO induced improvement of cardiac performance ... In rats with HF,
EPO increased
VEGF protein expression predominantly in cardiomyocytes, associated with a 37 % increase in capillary density and improved cardiac performance
Zhang et al., Front Biosci (Elite Ed) 2010
(Diabetic Retinopathy) :
The increased protein levels of HIF-1 alpha,
VEGF-A , and endogenous EPO found in diabetic retinas also have been
down-regulated by exogenous
EPO ... Exogenous
EPO at pharmacologic levels
leads to suppression of
VEGF and in turn, restoration of the normal functions of BRB in a time dependent manner
Wang et al., Am J Pathol 2012
(Retinal Neovascularization) :
In an in vitro study, hypoxia induced
VEGF inhibited
Epo gene expression by STAT3 activation in rat Müller cells