Gene interactions and pathways from curated databases and text-mining

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EPO — VEGFA

Text-mined interactions from Literome

Nitta et al., Eur J Pharmacol 1999 : Recombinant human erythropoietin stimulates vascular endothelial growth factor release by glomerular endothelial cells ... We designed the present study to address the question of whether recombinant human erythropoietin stimulates DNA synthesis and vascular endothelial growth factor ( VEGF ) secretion in vitro using cultured bovine glomerular endothelial cells ( GENs )
Batra et al., Lab Invest 2003 (Neoplasms, Germ Cell and Embryonal...) : Additionally, exogenous erythropoietin increased production and secretion of angiogenic growth factors, vascular endothelial growth factor , or placenta growth factor from the tumor cell lines, which promoted endothelial cell proliferation and chemotaxis
Tam et al., Nat Med 2006 (Polycythemia) : High-grade inhibition of VEGF induced hepatic synthesis of erythropoietin ( Epo, encoded by Epo ) > 40-fold through a HIF-1alpha independent mechanism, in parallel with suppression of renal Epo mRNA
Sturiale et al., Ren Fail 2007 (Acute Kidney Injury...) : Moreover, EPO can mobilize stem cells and increase the plasmatic levels and the renal expression of VEGF
Wang et al., J Cereb Blood Flow Metab 2008 : These in vitro results suggest that EPO enhances VEGF secretion in neural progenitor cells through activation of the PI3K/Akt and ERK1/2 signaling pathways and that neural progenitor cells treated with rhEPO upregulate VEGFR2 expression in cerebral endothelial cells, which along with VEGF secreted by neural progenitor cells promotes angiogenesis
Westenbrink et al., Cardiovasc Res 2010 (Disease Models, Animal...) : We intended to delineate the mechanisms of erythropoietin (EPO) induced cardiac vascular endothelial growth factor ( VEGF ) production and to establish if VEGF is crucial for EPO induced improvement of cardiac performance ... In rats with HF, EPO increased VEGF protein expression predominantly in cardiomyocytes, associated with a 37 % increase in capillary density and improved cardiac performance
Zhang et al., Front Biosci (Elite Ed) 2010 (Diabetic Retinopathy) : The increased protein levels of HIF-1 alpha, VEGF-A , and endogenous EPO found in diabetic retinas also have been down-regulated by exogenous EPO ... Exogenous EPO at pharmacologic levels leads to suppression of VEGF and in turn, restoration of the normal functions of BRB in a time dependent manner
Wang et al., Am J Pathol 2012 (Retinal Neovascularization) : In an in vitro study, hypoxia induced VEGF inhibited Epo gene expression by STAT3 activation in rat Müller cells