Gene interactions and pathways from curated databases and text-mining

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AKT1 — VCP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Meier et al., J Recept Signal Transduct Res 1999 (Second Messenger Systems) : Membrane recruitment driven by lipid second-messengers derived from PI 3-kinase leads to PKB phosphorylation and activation by upstream kinases ( PDK1 and an as yet identified protein kinase )
Klein et al., J Biol Chem 2005 (Anoxia) : PC-12 cells transfected with active Akt, but not dominant negative Akt or vector, induced VCP expression and an acidic shift in VCP pI, which was inhibited by protein phosphatase 2A treatment
Papadopoulou et al., Molecular cancer 2008 (Prostatic Neoplasms) : Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells
Yu et al., PloS one 2013 (Helicobacter Infections) : H. pylori infection increased the interaction between Akt and VCP, Akt dependent phosphorylation of VCP , levels of ubiquitinated proteins, and aggresome formation in AGS cells