Gene interactions and pathways from curated databases and text-mining

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PRKAR2A — VASP

Text-mined interactions from Literome

Li et al., Blood 2003 : Here we show that, in human platelets, phosphorylation of VASP at Ser239 induced by either cGMP analogs or nitric oxide ( NO ) donor glyco-SNAP1 is inhibited by PKA inhibitors KT5720, PKI, Rp-Br-cAMPS, and H89, but not by PKG inhibitors KT5823 or Rp-pCPT-cGMPS ... Unlike human platelets, cGMP analog induced phosphorylation of VASP in mouse platelets is inhibited by both PKG and PKA inhibitors ... Thus, PKA plays a predominant role in the cGMP induced phosphorylation of VASP and platelet inhibition in human platelets
Sudo et al., Platelets 2003 : The PKA/PKG inhibitor, H-89, inhibited VASP phosphorylation by cilostazol
Jensen et al., Blood 2004 : The protein kinase G ( PKG ) antagonist Rp-8-CPT-cGMPS strongly inhibited PKG mediated 46-kDa VASP Ser239 phosphorylation, but did not inhibit the thrombin induced shape change or the PKA mediated VASP Ser157 phosphorylation
Lin et al., J Cell Biol 2007 : Among actin associated proteins, Enabled ( Ena ) /vasodilator stimulated phosphoprotein ( VASP ) were predicted as PKA effectors downstream of syndecan-2, as Ena/VASP , which is activated by PKA , induces actin polymerization
Eckert et al., J Leukoc Biol 2007 : These data show that chemoattractant stimulation of human neutrophils induces a rapid and transient PKA dependent VASP Ser 157 phosphorylation
Benz et al., Int Immunopharmacol 2008 : Recently, we identified a novel interaction between alpha II-spectrin and vasodilator stimulated phosphoprotein ( VASP ), which is abrogated by the cAMP dependent protein kinase (PKA) mediated phosphorylation of VASP
Zhang et al., Mol Cell Biochem 2010 : Furthermore, disrupting PKA anchoring to AKAP or PKA activity significantly attenuated the PKA activity, VASP phosphorylation, and subsequent cell migration ... In conclusion, AKAP anchoring of PKA is an essential upstream event in regulation of PKA mediated VASP phosphorylation and subsequent endothelial cell migration, which contributes to explore new methods for controlling endothelial cell migration related diseases and angiogenesis
Bogatcheva et al., J Cell Physiol 2009 : Both VASP and filamin1 phosphorylation was significantly increased as a result of PKA activation ... Our data indicate that while PKA dependent VASP phosphorylation contributes to the protective effect of cAMP elicited on LPS compromised monolayers, filamin1 phosphorylation is unlikely to play a significant role in this process
Lee et al., Mol Cell Neurosci 2009 : PKA inhibitor effectively inhibited VASP phosphorylation and chemotaxis, indicating that P2Y12 mediated activation of PKA and subsequent VASP phosphorylation are involved in the regulation of microglia chemotaxis
Goncharova et al., Am J Respir Cell Mol Biol 2012 : Vasodilator stimulated phosphoprotein ( VASP ), an anticapping protein, modulates the formation of actin stress fibers during cell motility, and is negatively regulated by protein kinase A (PKA)-specific inhibitory phosphorylation at serine 157 ( Ser157 ) ... Here, we show that treatment with ß ( 2 ) AR agonists and PGE2 induces the PKA dependent phosphorylation of VASP and inhibits the migration of HASM cells