Gene interactions and pathways from curated databases and text-mining

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IGF1 — UCP3

Text-mined interactions from Literome

Gustafsson et al., Biochem Biophys Res Commun 2001 (Diabetes Mellitus, Type 2...) : In this study the expression of uncoupling protein 3 (UCP3) and its regulation by insulin-like growth factor 1 (IGF-I) and insulin in human neuroblastoma SH-SY5Y cells were characterized ... IGF-I induced a time- and concentration dependent induction of UCP3 protein reaching a twofold expression after 72 h with 10 nM IGF-I
Gustafsson et al., J Neurochem 2004 (MAP Kinase Signaling System) : We conclude that IGF-1 enhanced UCP3 expression at transcriptional level, primarily through the PI3-kinase dependent pathway and partly through the MAP kinase pathway
Gustafsson et al., J Neurosci Res 2004 (Diabetic Neuropathies...) : Insulin-like growth factor type 1 prevents hyperglycemia induced uncoupling protein 3 down-regulation and oxidative stress
Ramsay et al., Domest Anim Endocrinol 2008 : These experiments examined the potential roles of somatropin ( pST ) and IGF-I in the regulation of uncoupling protein (UCP)2 and UCP3 and their regulatory proteins peroxisome proliferator activated receptor ( PPAR) alpha, gamma and delta using in vivo pST treatment of swine and in vitro supplementation of pST or IGF-I to adipose slices