Gene interactions and pathways from curated databases and text-mining

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IGF1 — UCP1

Text-mined interactions from Literome

Ramsay et al., Domest Anim Endocrinol 2008 : These experiments examined the potential roles of somatropin ( pST ) and IGF-I in the regulation of uncoupling protein (UCP)2 and UCP3 and their regulatory proteins peroxisome proliferator activated receptor ( PPAR) alpha, gamma and delta using in vivo pST treatment of swine and in vitro supplementation of pST or IGF-I to adipose slices
Guerra et al., Biochem Biophys Res Commun 1994 : Confluent cells in a serum-free medium induced the expression of UCP in response to 1.4 nM IGF-I at 72 h, in a time dependent manner
Lorenzo et al., Cell Growth Differ 1996 : Moreover, IGF-I transactivation of UCP promoter was partially precluded by cotransfection with the dominant negative ras gene
Porras et al., DNA Cell Biol 1996 : IGF-I treatment of fetal brown adipocytes cotransfected with inducible gene constructs of SV40 large T antigen ( SV40LTag ) and a transforming ras gene induced uncoupling protein expression (UCP) in the absence of expression of the transfected genes ... These results indicate that Ras proteins mediate the IGF-I induced effect on UCP expression and play a role in the expression of IGF-I and IGF-I receptor
Teruel et al., J Cell Physiol 1998 : Transient transfection of dominant negative form of phosphatidylinositol (PI) 3-kinase completely blocked the transactivation of the fusion gene UCP1-CAT induced by either IGF-I or insulin, although inhibition of p70S6kinase with rapamycin does not preclude transactivation of the UCP1 promoter by insulin
Porras et al., Mol Endocrinol 1998 : Moreover, transient expression of a transfected active MEK construct ( R4F ) decreased IGF-I induced UCP-1 and insulin induced fatty acid synthase mRNA expression