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CASP7 — UCN

Text-mined interactions from Literome

Tang et al., Biochem Pharmacol 2000 (Leukemia) : Enforced expression of full-length Bcl-2 significantly protected cells ( at 24 hr ) from ara-C/UCN-01 induced caspase activation and apoptosis, but was ineffective in preventing loss of Deltapsi ( m ) and cytochrome c release
Wang et al., Mol Pharmacol 2003 (Leukemia, Myeloid) : Whereas bryostatin 1 and UCN-01 both markedly enhanced ara-C induced mitochondrial injury ( e.g., cytochrome c and Smac/DIABLO release, loss of mitochondrial membrane potential ), caspase activation, and apoptosis, ectopic expression of an N-terminal loop deleted Bcl-2 mutant protein protected cells from ara-C/UCN-01- but not ara-C/bryostatin 1-mediated lethality
Chan et al., Anticancer Drugs 2003 (Colonic Neoplasms) : In addition to Bcl-xL and p38 MAPK, UCN-01 also increased both caspase-3 and peroxisome proliferator activated receptor gamma protein levels
Dudgeon et al., Mol Cancer Ther 2010 : Deficiency in PUMA abrogated UCN-01 induced apoptosis, caspase activation, and mitochondrial dysfunction, and rendered UCN-01 resistance in a clonogenic assay, whereas elevated PUMA expression or a BH3 mimetic sensitized UCN-01 induced apoptosis