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IL5 — TYR

Text-mined interactions from Literome

Woodcock et al., EMBO J 1994 : Alanine substitutions in the region Tyr365-Ile368 in beta c showed that Tyr365 , His367 and Ile368 were required for GM-CSF and IL-5 high affinity binding, whereas Glu366 was unimportant
Woodcock et al., J Biol Chem 1996 : Significantly, reintroducing Tyr421 into the polyalanine substituted mutant restored high affinity ligand binding of GM-CSF, IL-3, and IL-5 , indicating that within this region the tyrosine residue alone is sufficient for high affinity ligand interaction