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AKT1 — TXNIP

Text-mined interactions from Literome

Chen et al., FASEB J 2008 (Diabetes Mellitus, Experimental...) : Thioredoxin interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes ... We further discovered that TXNIP deficiency induces Akt/Bcl-xL signaling and inhibits mitochondrial beta-cell death, suggesting that these mechanisms may mediate the beta-cell protective effects of TXNIP deficiency
Elgort et al., Genes & cancer 2010 : Mechanistically, Ras-MAPK and PI3K/Akt signaling inhibit TXNIP translation and MondoA dependent TXNIP transcription, respectively
Su et al., J Cell Mol Med 2013 (Hyperglycemia...) : Moreover, inhibition of p38 MAPK or activation of Akt markedly blocked HG-induced Txnip expression in I/R cardiomyocytes ... Hyperglycaemia enhances myocardial Txnip expression, possibly through reciprocally modulating p38 MAPK and Akt activation, leading to aggravated oxidative stress and subsequently, amplification of cardiac injury following MI/R