Gene interactions and pathways from curated databases and text-mining

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TPO — TTF1

Text-mined interactions from Literome

Ogasawara et al., Dev Genes Evol 2000 : TTF-1 regulates the expression of TPO , which encodes an iodinating enzyme associated with thyroid hormone synthesis ... A recent study showed that the ascidian TTF-1 and TPO genes are specifically expressed in the endostyle, but that the expression domains of these genes are not overlapping, suggesting that ascidian TPO is not regulated by TTF-1 ... Moreover, the spatial and temporal expression patterns of these genes suggest that TTF-1 regulates TPO expression ... The coexpression of these genes in amphioxus suggests that regulation of TPO by TTF-1 was present in the common ancestor of cephalochordates ( acraniates ) and craniates
Fenton et al., Ann Clin Lab Sci 2001 (Disease Progression...) : Thyroid transcription factor 1 ( TTF-1 ) is essential for thyroid differentiation and regulates expression of thyroglobulin, thyroid peroxidase , sodium/iodide symporter, and thyrotropin receptor ( TSH-R ) genes