Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — TSC1

Text-mined interactions from Literome

Pear et al., J Clin Invest 2010 (Neoplasms...) : New roles for Notch in tuberous sclerosis ... Although much remains to be learned about the precise mechanisms by which TSC loss leads to Notch activation, the newly identified link of TSC to Notch provides the rationale for testing Notch inhibitors in TSC associated tumors
Kapuria et al., PLoS Genet 2012 : Here we identify Notch mediated repression of Tuberous Sclerosis Complex 2 (TSC2) in EBs as a required step in the commitment of EBs into the EC fate