Gene interactions and pathways from curated databases and text-mining

◀ Back to AKT1

AKT1 — TSC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Potter et al., Nat Cell Biol 2002 : Stimulating Akt/PKB signalling in vivo markedly increases cell growth/size, disrupts the Tsc1-Tsc2 complex and disturbs the distinct subcellular localization of Tsc1 and Tsc2
Potter et al., Biochem Soc Trans 2003 : We have shown that Akt regulates the Tsc1-Tsc2 complex by directly phosphorylating Tsc2
Dan et al., J Immunol 2008 : mTOR is negatively controlled by the tuberous sclerosis complex 1/2 (TSC1/2) , and activation of Akt induces phosphorylation of TSC2, which blocks the repressive TSC1/2 activity
Pollizzi et al., Molecular cancer 2009 (Disease Models, Animal...) : Loss of either TSC1 or TSC2 in TSC hamartomas leads to activation of mTORC1 and suppression of AKT
Zhang et al., PloS one 2009 : Loss of function of the TSC1-TSC2 complex results in constitutive mTORC1 signaling and, through mTORC1 dependent feedback mechanisms and loss of mTORC2 activity, leads to a concomitant block of Akt signaling to its other downstream targets
Blancquaert et al., Mol Endocrinol 2010 : Unlike insulin, TSH/cAMP did not activate protein kinase B or induce tuberous sclerosis complex 2 phosphorylation at T1462 and Y1571
Vadlakonda et al., Frontiers in oncology 2013 : Akt phosphorylated at T308 inhibits TSC1/2 complex to activate mTORC1 ; mTORC2 is recognized as the kinase phosphorylating Akt at S473