Haga et al., Brain Res 2003
(Brain Ischemia...) :
In this study we examined the effects of 1,2-trifluoromethylphenyl imidazole (TRIM) , a novel neuronal nitric oxide synthase (nNOS) inhibitor , in three models of cerebral ischaemia ( global gerbil, global rat and focal rat )
Ulak et al., Pharmacol Biochem Behav 2010
:
The aim of this study is to investigate the involvement of 5-HT ( 1 ) and 5-HT(2) receptor subtypes in the antidepressant-like effect of TRIM , a nNOS inhibitor , in the rat forced swimming test (FST)
Handy et al., Br J Pharmacol 1996
:
3. The ability of TRIM to inhibit mouse cerebellar nNOS activity in vitro was influenced by the concentration of L-arginine ( 0.12-10.0 microM ) in the incubation medium ... The ability of TRIM to inhibit mouse cerebellar nNOS activity in vitro was unaffected by varying the time of exposure of the enzyme to TRIM from 0-60 min at 0 degree C. 4