Gene interactions and pathways from curated databases and text-mining

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MAPK3 — TRAF6

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → TRAF6 (increases, TRAF6 Activity)
    Evidence: TRAF6 activates the extracellular signal–regulated kinases (ERK) 1 and 2 as well as p38 mitogen-activated protein kinase (MAPK),11,118–125
  • KEGG Chagas disease (American trypanosomiasis): TRAF6 → MAPK1/MAPK3 (protein-protein, activation)
  • KEGG Tuberculosis: TRAF6 → MAPK1/MAPK3 (protein-protein, activation)

Text-mined interactions from Literome

Pullen et al., J Biol Chem 1999 : In contrast, p38 mitogen activated protein kinase activation was primarily dependent upon TRAF6 binding
Schultheiss et al., EMBO J 2001 (Cell Transformation, Viral...) : In TRAF6-knockout fibroblasts, significant induction of p38 MAPK by LMP1 is dependent on the ectopic expression of TRAF6
Li et al., American journal of physiology. Renal physiology 2002 : TRAF6 , in turn, activates SAPK/JNK and p38 MAPK phosphorylation, which in turn stimulates IL-8 and MCP-1 production in these cells
Matsuyama et al., J Immunol 2003 (MAP Kinase Signaling System) : Transfection of differentiated DDR1b overexpressing THP-1 cells with dominant negative TRAF6 completely abrogated DDR1b mediated p38 MAPK phosphorylation, indicating a critical role of TRAF6 in DDR1b mediated p38 MAPK activation
Mason et al., Infect Immun 2004 : TRAF6 dependent mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Horie et al., Microbes Infect 2007 (HIV Infections) : TRAF activation of C/EBPbeta ( NF-IL6 ) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages
Funakoshi-Tago et al., Cytokine 2009 : On the other hand, TRAF6 deficiency did not affect the TNFalpha induced activation of mitogen activated protein ( MAP ) kinases , ERK, JNK, and p38
Avila et al., Innate Immun 2012 : Lyn kinase controls TLR4 dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells