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MAPK14 — TRAF6

Pathways - manually collected, often from reviews:

• KEGG Chagas disease (American trypanosomiasis): TRAF6 → MAPK11/MAPK12/MAPK13/MAPK14 (protein-protein, activation)
  
• KEGG Tuberculosis: TRAF6 → MAPK11/MAPK12/MAPK13/MAPK14 (protein-protein, activation)
  
• NCI Pathway Database CD40/CD40L signaling: p38alpha-beta (MAPK14/MAPK11) → CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6) (modification, collaborate)
  Pullen et al., J Biol Chem 1999, Davies et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, assay
• NCI Pathway Database p38 MAPK signaling pathway: TRAF6 (TRAF6) → p38alpha-beta-active (MAPK14/MAPK11) (modification, activates)
  Wang et al., Nature 2001, Cheung et al., EMBO J 2003, Shibuya et al., Science 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of p38-alpha and p38-beta: p38alpha-beta (MAPK14/MAPK11) → TRAF6/MEKK3 complex (TRAF6-MAP3K3) (modification, collaborate)
  Huang et al., Nat Immunol 2004*
  Evidence: mutant phenotype, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of MAPK14-TAB1-MAPK14-TRAF6-TRAF6-TRAF6-TAB1-MAPK14-TAB1 (in vivo) Ge et al., Science 2002*
• IRef Hprd Interaction: MAPK14 — TRAF6 (in vivo) Baud et al., Genes Dev 1999*

Text-mined interactions from Literome

Pullen et al., J Biol Chem 1999 : In contrast, p38 mitogen activated protein kinase activation was primarily dependent upon TRAF6 binding
Schultheiss et al., EMBO J 2001 (Cell Transformation, Viral...) : In TRAF6-knockout fibroblasts, significant induction of p38 MAPK by LMP1 is dependent on the ectopic expression of TRAF6
Li et al., American journal of physiology. Renal physiology 2002 : TRAF6 , in turn, activates SAPK/JNK and p38 MAPK phosphorylation, which in turn stimulates IL-8 and MCP-1 production in these cells
Matsuyama et al., J Immunol 2003 (MAP Kinase Signaling System) : Transfection of differentiated DDR1b overexpressing THP-1 cells with dominant negative TRAF6 completely abrogated DDR1b mediated p38 MAPK phosphorylation, indicating a critical role of TRAF6 in DDR1b mediated p38 MAPK activation
Mason et al., Infect Immun 2004 : TRAF6 dependent mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Horie et al., Microbes Infect 2007 (HIV Infections) : TRAF activation of C/EBPbeta ( NF-IL6 ) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages
Funakoshi-Tago et al., Cytokine 2009 : On the other hand, TRAF6 deficiency did not affect the TNFalpha induced activation of mitogen activated protein ( MAP ) kinases , ERK, JNK, and p38
Avila et al., Innate Immun 2012 : Lyn kinase controls TLR4 dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells