Gene interactions and pathways from curated databases and text-mining

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CHUK — TRAF4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Takeuchi et al., Antioxid Redox Signal 2000 : Our data show that TRX treatment inhibits NF-kappaB dependent transcription at the level of downstream of TRAFs and upstream of NIK : TRX inhibited TRAF2-, TRAF5- , and TRAF6 induced NF-kappaB activation but does not inhibit NIK-, IKKalpha- , and MEKK induced activation
Kovalenko et al., Nature 2003 : CYLD has deubiquitinating activity that is directed towards non-K48 linked polyubiquitin chains, and negatively modulates TRAF mediated activation of IKK , strengthening the notion that ubiquitination is involved in IKK activation by TRAFs and suggesting that CYLD functions in this process
Sun et al., Mol Cell 2004 (Lymphoma, B-Cell, Marginal Zone) : RNAi mediated silencing of MALT1, TAK1, TRAF6 , and TRAF2 suppressed TCR dependent IKK activation and interleukin-2 production in T cells
Blackwell et al., Mol Cell Biol 2013 : Here, by assessing the kinetics and amplitude of I?B kinase ( IKK ) activation, we report that TNF-a induced immediate and robust activation of IKK requires K63 linked and linearly linked ubiquitination of RIP1 and that in the absence of RIP1 expression, TRAF2 and cIAP1 cooperatively induce delayed IKK activation by recruiting LUBAC to TNFR1